Dosing recommendations of drugs used in newborns with hypoxic ischaemic encephalopathy undergoing hypothermia as provided at the Dutch paediatric formulary are compared with some recommendations reported in literature80
| Recommendations as published | Dutch paediatric formulary | |||
| LD | MD | LD | MD | |
| Phenobarbital | 20–40 mg/kg | / | 20–40 mg/kg | 2.5–5 mg/kg in 1–2 doses/day |
| Morphine | 50 µg/kg | 5 µg/kg/hour | 50–100 µg/kg over 60 min | 3–20 µg/kg/hour |
| Midazolam | 0.05–0.1 mg/kg | 0.05–0.1 mg/kg/hour | 0.05 mg/kg | 0.05–0.1 mg/kg/hour maximum 24 hours |
| Lidocaine | >2.0–2.5 kg:2 mg/kg (10 min) <2.5–4.5 kg:2 mg/kg (10 min) | 6 mg/kg/hour (3.5 hours) → 3 mg/kg/hour (12 hours) → 1.5 mg/kg/hour (12 hours) 7 mg/kg/hour (3.5 hours) → 3.5 mg/kg/hour (12 hours) → 1.75 mg/kg/hour (12 hours) | 2 mg/kg (10 min) | 4 mg/kg/hour (6 hours) → 2 mg/kg/hour (12 hours) → stop |
| Topiramate | 15 mg/kg | 5 mg/kg/day | Not yet validated | Not yet validated |
| Erythropoietin | / | 1.000 U/kg every 24 hours (3×) then every 48 hours (2×) | Not yet validated | Not yet validated |
| Darbepoetin | / | 10 mcg/kg every 7 days (2×) | Not yet validated | Not yet validated |
| Gentamicin | / | 4–5 mg/kg every 36 hours (5×) | / | 5 mg/kg every 36 hours |
| Amikacin | / | 15 mg/kg every 36 hours | Not yet validated | Not yet validated |
LD, loading dose; MD, maintenance dose.