Study characteristics
| Characteristic | n |
| Type of study | 36 |
| Prospective observational | 28 |
| Retrospective observational | 6 |
| Mixed | 2 |
| Drug | |
| Antiepileptics | 9 |
| Phenobarbital* | 6 |
| Midazolam* | 3 |
| Lidocaine | 1 |
| Antibiotics | 12 |
| Gentamicin | 8 |
| Amikacin | 1 |
| Ampicillin | 1 |
| Amoxicillin | 1 |
| Benzylpenicillin | 1 |
| Analgesic/sedative | 3 |
| Morphine | 3 |
| Various neuroprotective | 11 |
| Erythropoietin | 2 |
| Darbepoetin | 2 |
| Topiramate | 3 |
| Bumetanide | 2 |
| Melatonin | 1 |
| 2-iminobiotin | 1 |
| Pharmacokinetic parameter | |
| Absorption | 3 |
| Distribution volume | 30 |
| Metabolic clearance | 6 |
| Excretion | 35 |
| Elimination half life† | 18 |
| Normothermic controls | |
| Yes | 10 |
| No | 26 |
*One study reported on both phenobarbital and midazolam pharmacokinetics.
†Elimination half life reflects both distribution and metabolic clearance/excretion.