Table 5

Termination rates

Author(s)Study locationStudy typeStudy population# of fetuses# of fetuses terminated (%)
Africa
de Paul Djientcheu et al22CameroonRetrospective descriptive observational studyInstitutional; patients with NTDs8 0 (0%)
Shalaby et al95EgyptRetrospective cross-sectional studyInstitutional; patients with urinary anomalies41 11 (26.8%)
Sorri and Mesfin43EthiopiaRetrospective cross-sectional studyMulti-centre; patients with NTDs at two tertiary hospitals177 13 (7.3%)
Akinmoladun et al44NigeriaProspective descriptive observational studyInstitutional; patients with lethal congenital anomalies5 4 (80%)
 Total4 studies, 4 countries3 retrospective, 1 prospective observational studies3 institutional, 1 multicentre23128
Median: 17.1%
Range: 0%–80%
Asia
Li et al96ChinaRetrospective descriptive observational surveyRegional; patients with NTDs160 72 (45%)
Lu et al33ChinaRetrospective cross-sectional studyNational (data from 20 counties); patients with NTDs361 355 (98.3%)
Xie et al91ChinaRetrospective descriptive observational studyInstitutional; patients with bronchopulmonary sequestration22 8 (36.4%)
Zhang et al97ChinaRetrospective descriptive observational studyInstitutional; patients with pulmonary sequestration68 2 (2.9%)
Kashyap et al98IndiaRetrospective descriptive observational studyInstitutional; patients with lethal congenital anomalies detected prior to 20 weeks of gestation103 80 (77.7%)
Kumar et al99IndiaProspective cohort studyInstitutional; patients with severe renal anomalies55 9 (16.4%)
Kumar et al100IndiaProspective descriptive observational studyInstitutional; patients with renal anomalies136 12 (8.8%)
Sanghvi et al56IndiaProspective descriptive observational studyInstitutional; patients with lethal renal anomalies7 2 (28.6%)
Samadirad et al39IranRetrospective descriptive observational studyRegional; patients with congenital anomalies603 201 (33.3%)
Munim et al63PakistanRetrospective cohort studyInstitutional; patients with diaphragmatic hernia41 6 (14.6%)
Hsieh et al101TaiwanRetrospective descriptive observational studyInstitutional; patients with CDH31 11 (35.5%)
Jaruratanasirikul et al102ThailandRetrospective cross-sectional studyRegional; patients with NTDs28 12 (42.9%)
Pitukkijronnakorn et al64ThailandProspective cross-sectional studyInstitutional; patients with congenital anomalies316 87 (27.5%)
Gammeltoft et al103VietnamEthnographic studyInstitutional; patients with congenital anomalies30 17 (56.7%)
 Total14 studies, 7 countries9 retrospective, 4 prospective observational studies; 1 ethnographic study10 institutional, 3 regional, 1 national1961 874
 Median: 34.4%
 Range: 2.9%–98.3%
Europe
Tudorache et al71RomaniaRetrospective descriptive observational studyInstitutional; patients with severe CDH diagnosed in the second trimester of pregnancy6 4 (66.7%)
Aygun et al73TurkeyRetrospective descriptive observational studyInstitutional; patients with NTDs72 0 (0%)
Oztarhan et al104TurkeyRetrospective cohort studyInstitutional; patients with lethal congenital anomalies1906 640 (33.6%)
Sahinoglu et al77TurkeyRetrospective case series (6 cases)Institutional; patients with body wall complex6 4 (66.7%)
 Total4 studies, 2 countries 4 retrospective observational studies 4 institutional1990648
Median: 50.2%
Range: 0%–66.7%
North America
Johnson et al42JamaicaRetrospective descriptive observational studyInstitutional; patients with congenital anomalies44 10 (22.7%)
 Total1 study, 1 country 1 retrospective observational study 1 institutional4410
Median: N/A
Range: N/A
South America
Brizot et al105BrazilRetrospective descriptive observational studyInstitutional; pairs of conjoined twins in which surgical separation was impossible and the condition lethal36 30 (83.3%)
Pelizzari et al106BrazilRetrospective cohort studyInstitutional; patients with anencephaly29 12 (41.4%)
 Total2 studies, 1 country 2 retrospective observational studies 2 institutional6542 (64.6%)
Median: 62.4%
Range: 41.4%–83.3%

  • CDH, congenital diaphragmatic hernia; NTD, neural tube defects.