Table 2

Effectiveness of antenatal ultrasound

Author(s)Study locationStudy typeStudy population# of women in study# of women who received antenatal diagnosis (%)
Africa
de Paul Djientcheu et al22CameroonRetrospective descriptive observational studyInstitutional; patients with NTDs admitted to neonatology unit278 (29.6%)
Sorri and Mesfin43EthiopiaRetrospective cross-sectional studyMulticentre; patients with NTDs at two tertiary hospitals177127 (71.8%)
Abdur-Rahman et al23NigeriaRetrospective descriptive observational studyInstitutional; patients with abdominal wall defects at a tertiary health centre in the North-Central geopolitical zone of Nigeria561 (1.8%)
Adeleye et al24NigeriaProspective cross-sectional studyInstitutional; patients presenting with major CNS anomalies at tertiary hospital436 (14%)
Adeleye and Joel-Medwase25NigeriaRetrospective cross-sectional surveyInstitutional; patients presenting with CNS anomalies at a neurosurgeon’s practice14626 (17.8%)
Akinmoladun et al44NigeriaProspective descriptive observational studyInstitutional; patients attending clinic for ultrasound screening1615 (93.8%)
Amadi and Eghwrudjakpor45NigeriaRetrospective descriptive observational studyInstitutional; all patients with encephalocele at tertiary hospital175 (29.4%)
Bankole et al26NigeriaProspective descriptive observational studyInstitutional; patients presenting with CNS anomalies at tertiary hospital1080 (0%)
Idowu and Olawehinmi27NigeriaProspective descriptive observational studyInstitutional; patients presenting with NTDs at tertiary hospital9123 (25.3%)
Okafor et al28NigeriaProspective cohort studyInstitutional; patients with PUV at tertiary hospital312 (6.5%)
Choopa et al46South AfricaRetrospective descriptive observational studyInstitutional; patients with PUV at paediatric nephrology unit6010 (16.7%)
Sekabira and Hadley29South AfricaRetrospective descriptive observational studyInstitutional; patients with gastroschisis at tertiary hospital10613 (12.3%)
Chanoufi et al47TunisiaRetrospective case series (6 cases)Institutional; cases of acardiac twins at maternity centre61 (16.7%)
Wesonga et al31UgandaProspective cohort studyInstitutional; patients with gastroschisis at a tertiary hospital411 (2.4%)
Munjanja et al32ZimbabweProspective descriptive observational studyInstitutional; patients with congenital anomalies at obstetrical unit9146 (50.5%)
Total15 studies, 7 countries8 retrospective, 7 prospective observational studies14 institutional, 1 multicentre1016284
Median: 16.7%
Range: 0%–93.8%
Asia
Deng et al48ChinaRetrospective cross-sectional studyNational; patients with omphalocele as reported in Chinese national birth defects monitoring network 1996–2006827322 (38.9%)
Hong et al49ChinaRetrospective cohort studyMulticentre; patients with gastroschisis173 (17.6%)
Liao et al50ChinaRetrospective descriptive observational studyInstitutional; patients with limb abnormalities at maternity and child health hospital3628 (77.8%)
Liu et al51ChinaRetrospective cross-sectional studyInstitutional; patients with congenital anomalies at a tertiary hospital23371 (30.5%)
Lu et al33ChinaRetrospective cross-sectional studyNational; patients with NTDs424361 (85.1%)
Shi et al52ChinaRetrospective descriptive observational studyInstitutional; cases of conjoined twins at tertiary hospital74 (57.1%)
Weng et al53ChinaRetrospective descriptive observational studyInstitutional; patients with congenital choledochal cyst at specialty women’s hospital2119 (90.5%)
Bhat et al34IndiaRetrospective descriptive observational studyInstitutional; patients admitted to NICU with CDH164 (25%)
Kumar et al54IndiaRetrospective descriptive observational studyInstitutional; symptomatic patients with congenital bronchopulmonary anomalies252 (8%)
Raman et al35IndiaRetrospective descriptive observational studyInstitutional; symptomatic patients with congenital cystic lung lesions at tertiary care centre403 (7.5%)
Rattan et al55IndiaRetrospective descriptive observational studyInstitutional; patients operated on for oesophageal atresia and tracheoesophageal fistula at a tertiary care centre69363 (9.1%)
Sanghvi et al56IndiaProspective descriptive observational studyInstitutional; patients with renal anomalies at tertiary centre12565 (52%)
Sarin et al57IndiaRetrospective case series (18 cases)Institutional; patients with duodenal webs at tertiary hospital in India182 (11.1%)
Sharada et al58IndiaRetrospective descriptive observational studyInstitutional; patients diagnosed with unilateral multicystic dysplastic kidney at tertiary hospital4734 (72.3%)
Singh et al59IndiaRetrospective descriptive observational studyInstitutional; patients with unilateral multicystic dysplastic kidney at tertiary centre2212 (54.5%)
Solanki et al60IndiaRetrospective case series (6 cases)Institutional; patients diagnosed with crossed fused renal ectopia at tertiary hospital61 (16.7%)
Kazmi et al38IranProspective descriptive observational studyInstitutional; patients referred to tertiary centre for myelomeningocele evaluation and management13633 (24.3%)
Mirshemirani et al61IranRetrospective descriptive observational studyInstitutional; patients treated for PUV at a tertiary hospital9820 (20.4%)
Shahkar et al62IranRetrospective descriptive observational studyInstitutional; patients with congenital pulmonary mass at a tertiary hospital4710 (21.3%)
Ho et al40MalaysiaRetrospective cohort studyRegional; births in Kinta District (253 cases with congenital anomalies and 506 control cases)25237 (14.7%)
Munim et al63PakistanRetrospective cohort studyInstitutional; patients with diaphragmatic hernia at tertiary hospital6541 (63.1%)
Kitisomprayoonkul and Tongsong41ThailandProspective descriptive observational studyInstitutional; patients with NTDs at tertiary hospital4242 (100%)
Pitukkijronnakorn et al64ThailandProspective cross- sectional studyInstitutional; patients diagnosed with major congenital anomalies at tertiary hospital316144 (45.6%)
Srisupundit et al65ThailandProspective descriptive observational studyInstitutional; patients undergoing antenatal ultrasound at a university teaching hospital in Chiang Mai3424 (70.6%)
Total24 studies, 6 countries19 retrospective, 5 prospective observational studies20 institutional, 1 multicentre, 1 regional, 2 national35471345
Median: 34.7%
Range: 7.5%–100%
Europe
Iliescu et al66RomaniaProspective descriptive observational studyMulticentre; patients at two institutions with major congenital anomalies7674 (97.4%)
Ognean et al67RomaniaRetrospective case series (7 cases)Institutional; patients with oesophageal atresia at a tertiary centre70 (0%)
Tarca and Aprodu68RomaniaRetrospective descriptive observational studyInstitutional; patients with omphalocele at tertiary hospital10514 (13.3%)
Tarca and Aprodu69RomaniaRetrospective descriptive observational studyInstitutional; patients with gastroschisis at tertiary hospital549 (16.7%)
Tarca et al70RomaniaRetrospective descriptive observational studyInstitutional; patients with gastroschisis at tertiary hospital11413 (11.4%)
Tudorache et al71RomaniaRetrospective descriptive observational studyInstitutional; patients with cases of left-sided CDH at tertiary hospital2111 (52.4%)
Postoev et al 72RussiaRetrospective cross-sectional studyRegional; patients with congenital anomalies in the Kola Peninsula (data from two birth defect registries)23281 (34.9%)
Aygun et al73TurkeyRetrospective descriptive observational studyInstitutional; patients with NTDs at tertiary hospital10072 (72%)
Dane et al74TurkeyProspective descriptive observational studyInstitutional; fetuses with incurable congenital anomalies and curable severe congenital anomalies at a training and research hospital2423 (95.8%)
Orgul et al75TurkeyRetrospective descriptive observational studyInstitutional; patients with gastrointestinal tract malformations at a university children’s hospital5634 (60.7%)
Oztekin et al76TurkeyProspective descriptive observational studyInstitutional; patients with a major structural congenital anomaly at an obstetrics and gynaecology teaching hospital2119 (90.5%)
Sahinoglu et al77TurkeyRetrospective case series (6 cases)Institutional; patients with limb body wall complex at a women and children’s research hospital65 (83.3%)
Tabel et al78TurkeyProspective descriptive observational studyInstitutional; patients with kidney or urinary tract anomalies at a university hospital7632 (42.1%)
Taskapilioglu et al79TurkeyRetrospective descriptive observational studyInstitutional; patients with open spina bifida at tertiary centre7826 (33.3%)
Total14 studies, 3 countries10 retrospective, 4 prospective observational studies12 institutional, 1 multicentre, 1 regional970413
Median: 47.3%
Range: 0%–97.4%
North America
Johnson et al42JamaicaRetrospective descriptive observational studyInstitutional; patients with congenital anomalies at tertiary hospital5744 (77.2%)
Total1 study, 1 country1 retrospective observational study1 institutional5744
Median: N/A
Range: N/A
South America
Campana et al80Argentina, Brazil, Chile, and VenezuelaProspective descriptive observational studyMulticountry; patients with congenital anomalies in 18 Latin American hospitals812457 (56.3%)
Germani et al81ArgentinaRetrospective descriptive observational studyInstitutional; patients with choledochal cyst at a private hospital124 (33.3%)
Wyszynski et al82ArgentinaSurveyInstitutional; patients with non-syndromic oral cleft (collected from parents’ survey data)1657 (4.2%)
Carvalho et al83BrazilProspective cohort studyInstitutional; patients with major congenital anomalies at a tertiary hospital13093 (71.5%)
Luiza et al84BrazilRetrospective cross-sectional studyInstitutional; patients with orofacial cleft at a specialised society attending to cleft patients1687 (4.2%)
Tannuri et al85BrazilRetrospective descriptive observational studyMulticentre; patients with gastroschisis at three tertiary centres163134 (82.2%)
Vilela et al86BrazilRetrospective cross-sectional studyInstitutional; patients with gastroschisis at a tertiary hospital3110 (32.3%)
Correa et al87ColombiaRetrospective case-control studyCity-wide; data from Bogota Congenital Malformations Surveillance Program16782 (49.1%)
de Rovetto et al88ColombiaRetrospective descriptive observational studyCity-wide; patients with congenital renal agenesis at centres in Cali, Colombia388 (21.1%)
Rosselli et al89ColombiaRetrospective descriptive observational studyCity-wide; patients with congenital talipes equinovarus in Bogota, Colombia17861 (34.3%)
Saldarriaga et al90ColombiaRetrospective cross-sectional studyCity-wide; patients with congenital anomalies diagnosable by antenatal ultrasound in NICUs of Cali, Colombia217117 (53.9%)
Total11 studies, 5 countries8 retrospective, 2 prospective observational studies, 1 survey5 institutional, 1 multicentre, 4 city-wide, 1 multicountry2078980
Median: 34.3%
Range: 4.2%–82.2%
  • CDH, congenital diaphragmatic hernia; CNS, central nervous system; NICU, neonatal intensive care unit; NTD, neural tube defects; PUV, posterior urethral valves.