RTT comorbidities | Prevalence (%) | Studies |
Neurological | ||
Irregular breathing pattern | 95 | Tarquinio et al16 |
Epilepsy | 90 | Tarquinio et al17 |
Dysphagia | 90 | Motil et al29 |
Sleep dysfunction | 93 | Boban et al31 |
80 | Wong et al23 | |
Movement disorders | 84 | Humphreys et al20 |
63 | Temudo et al21 | |
63 | FitzGerald et al22 | |
Behavioural disturbance, any | 97 | Buchanan et al15 |
Behavioural disturbance (on med) | 14 | |
Gastrointestinal/nutrition | ||
Constipation | 80 | Motil et al29 |
Reflux | 40 | Motil et al29 |
Growth abnormalities | 40 | Motil et al29 |
Underweight | 38 | |
Short stature | 45 | |
Gall bladder dysfunction | 4 | Motil et al30 |
Cardiac | ||
Prolonged QT interval | 18 | McCauley, et al25 |
10 | Crosson et al26 | |
Endocrine | ||
Low bone mineral mass | 59 | Motil et al28 |
Premature adrenarche | 28 | Killian et al18 |
Premature thelarche | 25 | Killian et al18 |
Delayed menarche | 19 | Killian et al18 |
Thyroid dysfunction | 18 | Stagi et al27 |
Orthopaedic | ||
Scoliosis | 80 | Percy et al19 |
Hip displacement | 50 | Tay et al32 |
Fractures | 32 | Jefferson et al24 |
28 | Motil et al28 |
RTT, Rett syndrome.