Baseline | Intervention | P value | |
N=82 | N=63 | ||
3478 patient-days | 2573 patient-days | ||
Antibiotic use, days per 1000 patient-days | 534 (517 to 551)* | 466 (447–485) | <0.001 |
Treatment | 287 (272 to 302)* | 197 (182–213) | <0.001 |
Prophylaxis | 247 (233 to 262)* | 269 (253–287) | 0.05 |
Mortality | 7 (9%)† | 6 (10%) | 0.84 |
Infection-related late deaths (>24-hour age) | 2 (2%)† | 1 (2%) | 0.60 |
Reinitiation of antibiotics within 72 hours | 9 (11%)† | 1 (2%) | 0.04 |
Did not receive antibiotic treatment | 17 (21%)† | 28 (44%) | 0.002 |
Antibiotic treatment episodes, n | 99 | 49 | |
Early-onset infection | 18 (18%)† | 7 (14%) | 0.55 |
Treatment length (days) | 8 (1–61)‡ | 6 (1–39) | 0.08 |
Treatment duration (≤5 days) | 22 (22%)† | 19 (39%) | 0.03 |
Culture-positive sepsis | |||
No of episodes | 15 (15%)†§ | 4 (8%)¶ | |
Treatment length (days) | 10 (2–17)‡ | 9 (1–10) | 0.36 |
CoNS sepsis | |||
No of episodes | 9 (9%)† | 4 (8%) | |
Treatment length (days) | 7 (4–8)‡ | 10.5 (5–23) | 0.18 |
Culture-negative infection | |||
No of episodes | 62 (63%)† | 23 (47%) | |
Treatment length (days) | 9 (1–61)‡ | 6 (1–39) | 0.10 |
Without confirmed infection | |||
No of episodes | 13 (13%)† | 18 (37%) | |
Treatment length (days) | 8 (3–20)‡ | 6 (2–19) | 0.49 |
*N (95% CI).
†N (%).
‡Median (range).
§Serratia marcescens (n=5), Staphylococcus aureus (n=5), Enterococcus faecalis (n=2), Klebsiella oxytoca (n=1), Enterobacter cloacae (n=1), Group B Streptococcus (n=1).
¶Group B Streptococcus (n=1), S. aureus (n=1), Streptococcus anginosus (n=1), S. salivarius (n=1).
CoNS, coagulase-negative Staphylococcus spp.