Table 3

Patient demographics and outcomes for infants born >34 weeks’ gestation admitted to neonatal units in England and treated with iNO

2010–20112012–20132014–2015
Neonatal admissions requiring ≥1 day of intensive care (with and without iNO)18 37422 77727 872
Infants treated with iNO820 (4.5%*)1015 (4.5%*)1400 (5.0%*)
Birth weight (g)3273 (2840,3665)3240 (2760,3690)3220* (2680,3630)
Gestational age (weeks)40 (38,41)39 (37,40)39 (37,40)
Male sex450 (54.9%)577 (56.9%)756 (54.0%)
Prolonged rupture of membranes >24 hours§82 (10.0%)92 (9.1%)68 (4.9%)
Surfactant therapy in labour ward or neonatal unit532 (64.9%)613 (60.4%)713 (50.9%)
Initiation of iNO therapy (days)2 (1,2)2 (1,2)2 (1,2)
Duration of iNO therapy (days)3 (2,5)3 (2,5)2 (1,5)
Diagnosis (not mutually exclusive)‡
Respiratory distress syndrome259 (31.6%)378 (37.2%)778 (55.6%)
Pulmonary hypoplasia61 (7.4%)67 (6.6%)101 (7.2%)
Meconium aspiration syndrome314 (38.3%)378 (37.2%)440 (31.4%)
Pulmonary hypertension598 (72.9%)703 (69.3%)885 (63.2%)
Congenital pneumonia42 (5.1%)52 (5.1%)74 (5.3%)
Congenital diaphragmatic hernia55 (6.7%)57 (5.6%)83 (5.9%)
Death among infants who received iNO165 (20.1%)160 (15.8%)212 (15.1%)
  • The denominator for all proportions is the number of babies treated with iNO unless indicated otherwise.

  • One baby with a birth weight less than 300 grams was removed from this calculation (n=1399).

  • *Denominator is all admissions to neonatal unit admissions requiring ≥1 day of intensive care. All values are given as n, % or median (25th,75th centiles) as appropriate.

  • †This includes the diagnosis respiratory distress syndrome and signs of respiratory distress of newborn (see online supplemental file 1).

  • ‡Extracted codes available in online supplemental file.

  • §Prolonged rupture of membranes >24 hours uses a combination of discharge diagnoses and recorded duration of rupture of membranes.

  • iNO, inhaled nitric oxide.