Table 1

The three choices offered to parents regarding which genes will be analysed and reported following whole-exome sequence

Choice AChoice BChoice C
Only genes that are known to cause hearing loss will be examined. We estimate that we will identify a genetic cause for hearing loss in about half of the infants that we test.Choice B is the same as Choice A 
plus 
We will analyse additional genes that cause diseases that:

  1. affect children

  2. have a known treatment or intervention that will improve the child’s health.

Choice C is the same as Choice B 
plus 
We will analyse additional genes that cause diseases that:

  1. affect children

  2. may not have a clear treatment pathway or intervention to improve the child’s health.