Association between hypoglycaemia and death and/or disability at different blood glucose level thresholds (multivariable analysis)
| Threshold of 2.6 mmol | Threshold of 3.0 mmol/L | |||||||
| In first 12 hours | p Value | Over 72 hours | p Value | In first 12 hours | p Value | Over 72 hours | p Value | |
| Adjusted OR and 95% CI (HIE stage) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.54 (0.09 to 3.15) | 0.493 | 0.39 (0.06 to 2.44) | 0.314 | 0.41 (0.07 to 2.51) | 0.332 | 0.39 (0.06 to 2.40) | 0.307 |
| Two episodes | 0.711 (0.07 to 6.85) | 0.768 | 0.31 (0.03 to 3.81) | 0.357 | 1.35 (0.21 to 8.59) | 0.748 | 0.44 (0.03 to 6.71) | 0.552 |
| Three or more episodes | 10.76 (1.94 to 59.62) | 0.007 | 6.55 (1.19 to 36.09) | 0.031 | 5.69 (1.08 to 29.97) | 0.040 | 2.23 (0.58 to 8.56) | 0.241 |
| Adjusted OR and 95% CI (HIE stage and hyperglycaemia) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.60 (0.10 to 3.46) | 0.563 | 0.43 (0.07 to 2.63) | 0.359 | 0.44 (0.07 to 2.68) | 0.373 | 0.41 (0.07 to 2.55) | 0.337 |
| Two episodes | 0.77 (0.07 to 8.23) | 0.828 | 0.31 (0.02 to 4.24) | 0.382 | 1.46 (0.22 to 9.89) | 0.697 | 0.44 (0.03 to 7.06) | 0.565 |
| Three or more episodes | 11.79 (2.03 to 68.50) | 0.006 | 6.91 (1.23 to 38.78) | 0.028 | 6.07 (1.12 to 33.08) | 0.037 | 2.33 (0.59 to 9.28) | 0.229 |
| Adjusted OR and 95% CI (HIE stage and time to start TH) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.58 (0.09 to 3.57) | 0.558 | 0.41 (0.06 to 2.74) | 0.358 | 0.44 (0.07 to 2.84) | 0.387 | 0.41 (0.06 to 2.64) | 0.345 |
| Two episodes | 0.52 (0.03 to 8.80) | 0.649 | 0.33 (0.03 to 4.27) | 0.395 | 1.35 (0.18 to 10.48) | 0.772 | 0.44 (0.03 to 6.90) | 0.555 |
| Three or more episodes | 11.96 (2.07 to 69.17) | 0.006 | 7.09 (1.19 to 42.33) | 0.032 | 6.28 (1.14 to 34.54) | 0.035 | 2.50 (0.60 to 10.4) | 0.211 |
| Adjusted OR and 95% CI (HIE stage, hyperglycaemia and time to start TH) | ||||||||
| Nil episodes | Baseline | Baseline | ||||||
| One episode | 0.71 (0.12 to 4.32) | 0.713 | 0.50 (0.08 to 3.17) | 0.459 | 0.52 (0.08 to 3.20) | 0.481 | 0.47 (0.07 to 2.95) | 0.418 |
| Two episodes | 0.63 (0.03 to 13.89) | 0.770 | 0.34 (0.02 to 5.38) | 0.446 | 1.66 (0.19 to 14.41) | 0.647 | 0.46 (0.03 to 7.92) | 0.590 |
| Three or more episodes | 15.03 (2.32 to 97.19) | 0.004 | 8.15 (1.31 to 50.58) | 0.024 | 7.42 (1.25 to 44.08) | 0.028 | 2.87 (0.63 to 12.94) | 0.171 |
HIE, hypoxic ischaemic encephalopathy; TH, therapeutichypothermia.