Table 1

Cytokine production in children and adults with SARS-CoV-2 infection20 26 32 33


AdultsChildren
SevereMildAsymptomaticPIMS-TSSevereMildAsymptomatic
CYTOKINES





↑IL-6↑IL-6↔IL-6↑IL-6↔IL-6↔IL-6↔IL-6
↑ IL-10↑IL-10↑ IL-10↑ IL-10↑ IL-10↑ IL-10↑ IL-10
↑IFN↑ IFN↔IFN↑IFN↑/↔IFN↑/↔IFN↔IFN
↑ TNFα↑ TNFα↔ TNFα↑ TNFα↔ TNFα↔ TNFα↔ TNFα
↑/↔ IL-1β↑/↔ IL-1β↔ IL-1βn/a↔ IL-1β↔ IL-1β↔ IL-1β
↑/↔ IL-8↑/↔ IL-8↔ IL-8↑ IL-8↑ IL-8↔ IL-8↔ IL-8
↑/↔ IL-17↑/↔ IL-17↔ IL-17↑ IL-17↑/↔ IL-17↑/↔ IL-17↔ IL-17
  • ↑, increased; ↓, decreased; ↔, unchanged.

  • IFN, interferon; IL, interleukin; n/a, not available; PIMS-TS, paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2; TNF-α, tumour necrosis factor alpha.