Study | Year | No | Age | Regimen 1 | Regimen 2 | Main outcomes reported in the study | Context | Randomisation | Allocation concealment | Blinding | Incomplete outcomes | Selective reporting | Other |
Trautwein et al 1 | 1996 | 140 | 5–18 years | X-Pep and sodium phosphate | Magnesium citrate and sodium phosphate | No significant different reported between bowel preparations for the two regimens. No safety concerns were raised, but numbers of adverse events were not described | Elective colonoscopy | Unclear | Unclear | Unclear | Unclear | Unclear risk | None apparent |
Pinfield and Stringer14 | 1999 | 63 | 18 months–16 years | Picolax | Bisacodyl+phosphate enema | Bowel preparation was good or excellent in all of the patients in the picolax group (n=32) compared with 22 patients in the bisacodyl phosphate enema group (n=31). Abdominal discomfort was reported by seven in the picolax group vs 18 in the bisacodyl group and vomiting by three in the picolax group and 0 in the bisacodyl group | Elective colonoscopy | Unclear | Sealed envelopes | Single blind | High risk—only adverse events | High risk | None apparent |
Elitsur et al 17 | 2013 | 93 | Mean 10 years | 4-day protocol PEG 3350 | 2-day protocol PEG 3350+bisacodyl | Adequate colon preparation was reached in 57.5% of regimen 1% and 73.6% of regimen 2. Side effects were reported as minimal and comparable in both groups (abdominal pain: 26%–32%, vomiting: 2%). None of the children discontinued his protocol due to side effects | Elective colonoscopy | Computer-generated random list | Unclear | Unclear | Unclear | High risk | None apparent |
Sorser et al 16 | 2014 | 32 | 2–21 years | 1-day PEG 3350 Max 255 g | 3-day PEG 3350 max 85 g/day | A grading of excellent or good was given to 18/18 in regimen 1 and 13/14 in regimen 2. In regimen 1, 5 reports of minor side effects were made versus 10 reports in regimen 2. | Elective colonoscopy | No detail given | Unclear | Single blind | Low risk | Low risk | None apparent |
Najafi et al 15 | 2015 | 100 | 2–14 years | 1 day 2 g/kg PEG+Bisacodyl Suppository | 2 day 1.5 g/kg PEG+Bisacodyl suppository | A grading of excellent or good was given to 35/50 in regimen 1 and 36/50 in regimen 2. Regimen 1 8/18 complained of nausea, 1/18 vomiting and 4/18 abdominal pain vs 3/14 nausea, 2/14 vomiting and 3/14 of abdominal pain in regimen 2. | Elective colonoscopy | Computer-generated random numbers | A technician randomly assign | Single blind | Low risk | Low risk | None apparent |
El-Baba et al 18 | 2006 | 62 | 4–18 years | Prepackaged food kit, magnesium citrate | Sodium phosphate | Quality of colon cleansing rated as excellent in 50% of regimen 1% and 19% of regimen 2. 30/36 in group 1 reported minor side effects versus 26/26 in group 2. | Elective colonoscopy | Computer random number generator | Unclear | Single blind | Unclear | Low risk | None apparent |
PEG, polyethylene glycol.