Table 2

Primary and secondary outcome variables

Primary outcomes
Primary outcomesPrimary outcome variables
Improvement in end organ perfusion
  • SBP

  • DBP

  • MBP

  • Urine output

  • Inotropic support

  • Serum lactate

Mortality
  • Death before discharge

Secondary outcomesSecondary outcome variables
Major neurosensory disabilityNeurosensory disability
  • Moderate to severe motor or cognitive impairment

  • Severe visual or hearing impairment

Occurrence of adverse eventsAdverse events
  • Peripheral tissue ischaemia

  • Gastrointestinal events

  • Renal events

  • Hepatic events

  • Hyponatraemia

  • The secondary outcomes will be defined as reported in the primary studies.

  • DBP, diastolic blood pressure; MBP, mean blood pressure; SBP, systolic blood pressure.