Table 1

Copper and zinc concentrations in colostrum and transitional breast milk from mothers with Wilson’s disease who were undergoing treatment for the disease and in control milk

MedicationSubjects (n)Dosage
Sample date after delivery (days)Serum concentrations of copper and zinc in mothers (µg/dL)Concentrations of copper and zinc in breast milk (µg/dL)
mean±SD (minimum–maximum)
Copper (each value)ZincCopperZinc
Colostrum (0–4 days after delivery)
 TE21500 and 17502 and 316 and 18N.E.15 and 64838 and 1448
 No medication (healthy controls)21N.M.1–4N.E.N.E.39±8 (16–50)614±292 (218–1227)
Transitional breast milk (5–13 days after delivery)
 TE21500 and 17505 and 1016 and 18N.E.35 and 59653 and 838
 PC3300–800619, 21, 22N.E.51 (44–60)387 (273–452)
 Zinc21006 and 1213 and 37N.E.28 and 61317 and 452
  • Mean age (minimum–maximum) at diagnosis and delivery of patients were 13 (9–29) years and 31 (23–38) years, respectively.

  • *Control data were comparable to those from a previous report.16

  • NE, not examined; NM, no medication; PC, penicillamine; TE, trientine.