Table 2

Relationship between brain abnormality scores and suboptimal neurobehaviour

Suboptimal neurobehaviourGlobal brain abnormality score
OR (95% CI), p Value
Cerebral WM brain abnormality score
OR (95% CI), p Value
Cortical grey matter abnormality score
OR (95% CI), p Value
Deep nuclear grey matter abnormality score
OR (95% CI), p Value
Cerebellar abnormality score
OR (95% CI), p Value
NNNS attention1.03 (0.87 to 1.21), 0.671.18 (0.91 to 1.53), 0.200.75 (0.50 to 1.13), 0.161.59 (0.42 to 5.95), 0.501.08 (0.61 to 1.90), 0.80
NNNS arousal0.93 (0.82 to 1.04), 0.210.89 (0.72 to 1.09), 0.261 (0.77 to 1.28), 0.980.74 (0.29 to 1.92), 0.540.77 (0.48 to 1.25), 0.30
NNNS regulation0.99 (0.89 to 1.11), 0.881.01 (0.84 to 1.21), 0.940.98 (0.76 to 1.27), 0.900.21 (0.03 to 1.30), 0.091.01 (0.69 to 1.47), 0.97
NNNS handling0.85 (0.68 to 1.07), 0.160.72 (0.42 to 1.23), 0.231.08 (0.78 to 1.51), 0.65Omitted*0.51 (0.18 to 1.44), 0.20
NNNS quality of movement1.07 (0.94 to 1.21), 0.311.07 (0.87 to 1.32), 0.511.02 (0.78 to 1.34), 0.880.44 (0.11 to 1.70), 0.231.45 (0.97 to 2.16), 0.07
NNNS excitability0.93 (0.83 to 1.05), 0.250.87 (0.71 to 1.06), 0.171.05 (0.83 to 1.35), 0.670.20 (0.03 to 1.50), 0.120.85 (0.57 to 1.27), 0.43
NNNS lethargy1.20 (1.01 to 1.43), 0.041.44 (1.09 to 1.89), 0.010.78 (0.47 to 1.27), 0.32Omitted*2.22 (1.38 to 3.59),<0.01
NNNS non-optimal reflexes1.23 (1.07 to 1.41),<0.011.30 (1.06 to 1.59), 0.011.33 (1.03 to 1.72), 0.031.12 (0.36 to 3.53), 0.851.47 (0.97 to 2.23), 0.07
NNNS asymmetrical reflexes0.86 (0.69 to 1.08), 0.200.89 (0.63 to 1.26), 0.520.83 (0.50 to 1.36), 0.45Omitted*0.43 (0.18 to 1), 0.05
NNNS hypertonicity1.07 (0.92 to 1.24), 0.401.17 (0.91 to 1.52), 0.231.07 (0.78 to 1.47), 0.68Omitted*0.99 (0.58 to 1.68), 0.97
NNNS hypotonicity1.05 (0.93 to 1.19), 0.401.21 (1 to 1.46), 0.050.92 (0.67 to 1.27), 0.62Omitted*1.08 (0.67 to 1.73), 0.75
NNNS stress1.10 (0.98 to 1.22), 0.111.15 (0.96 to 1.38), 0.121.05 (0.84 to 1.32), 0.660.90 (0.37 to 2.16), 0.811.35 (0.91 to 1.99), 0.13
HNNE total score1.19 (1.05 to 1.33),<0.011.29 (1.06 to 1.57), 0.011.16 (0.91 to 1.49), 0.230.68 (0.23 to 2.02), 0.491.61 (1.09 to 2.38), 0.02
HNNE tone optimality1.10 (0.97 to 1.23), 0.141.14 (0.94 to 1.38), 0.171 (0.77 to 1.29), 0.971.38 (0.58 to 3.29), 0.461.55 (1.02 to 2.34), 0.04
HNNE tone patterns1.13 (0.98 to 1.31), 0.101.09 (0.86 to 1.37), 0.481.22 (0.87 to 1.70), 0.250.54 (0.09 to 3.06) 0.481.50 (0.91 to 2.46), 0.11
HNNE reflexes1.17 (1.03 to 1.33), 0.011.37 (1.09 to 1.71), 0.011.05 (0.80 to 1.39), 0.720.38 (0.05 to 2.76), 0.341.41 (0.94 to 2.12), 0.10
HNNE spontaneous movement1.11 (0.98 to 1.25), 0.091.26 (1.04 to 1.52), 0.021.04 (0.81 to 1.35), 0.740.42 (0.10 to 1.88), 0.261.15 (0.77 to 1.72), 0.50
HNNE abnormal signs1.14 (1.01 to 1.28), 0.031.12 (0.93 to 1.34), 0.241.23 (0.94 to 1.61), 0.131.09 (0.44 to 2.69), 0.861.34 (0.88 to 2.06), 0.18
HNNE behaviour1.11 (0.90 to 1.36), 0.321.20 (0.89 to 1.63), 0.231.02 (0.66 to 1.58), 0.94Omitted*1.52 (0.84 to 2.74), 0.16
Abnormal GMs1.12 (0.99 to 1.26) 0.071.21 (1.00 to 1.46) 0.051.15 (0.91 to 1.45) 0.240.92 (0.41 to 2.05) 0.841.04 (0.71 to 1.53) 0.83
  • *Result omitted as too few numbers with suboptimal neurobehaviour and deep nuclear grey matter abnormality to analyse.

  • GMs, general movements; HNNE, Hammersmith Neonatal Neurological Examination; NNNS, Neonatal Intensive Care Unit Network Neurobehavioral Scale; WM, white matter.