Table 2

Primary and secondary outcome variables*



Primary outcomes		Primary outcome variables
Improvement in end-organ perfusion

  • SBP

  • DBP

  • MBP

  • Urine output

  • Inotropic support

  • Serum lactate

Mortality

  • Death before discharge

Secondary outcomesSecondary outcome variables†
Major neurosensory disability

  • Moderate to severe motor impairment

  • Moderate to severe cognitive impairment

  • Cerebral palsy

  • Visual impairment

  • Hearing impairment

BPD
Occurrence of adverse events		Adverse events

  • Hyperglycemia

  • Gastrointestinal events

  • Hospital-acquired infection

  • Hypertension

  • *The primary and secondary outcome variables are defined as per the primary studies.

  • †For all secondary outcome variables, the number or % in exposed versus unexposed groups; attributed to hydrocortisone will be applied for the analysis.

  • BPD, bronchopulmonary dysplasia; DBP, diastolic blood pressure; MBP, mean blood pressure; SBP, systolic blood pressure.