Table 1

Characteristics of the study population

Maternal characteristics
 Age (years)2731.0 (4.9)
 Race: White2724 (88.9%)
 University qualification2613 (50.0%)
Pregnancy characteristics27
 Primiparous17 (63.0%)
 Induction of labour3 (11.1%)
 Pregnancy complications†5 (14.8%)
 Intrapartum complications‡23 (85.2%)
 Lower segment caesarean section (LSCS)11 (40.7%)
 Breech2 (7.4%)
 Pyrexia >38°C, n (%)0 (0.0%)
Paternal characteristics
 Age (years)2639.5 (1.6)
 Race: White2521 (84.0%)
 University qualification209 (45.0%)
Infant characteristics27
 Sex (male)19 (70.4%)
 Gestation weeks (mean (SD))39.5 (1.5)
 Birth weight g, mean (SD)3314 (468)
 Head circumference cm, mean (SD)34.8 (1.3)
 Transferred from LNU or SCBU for cooling17 (63.0%)
 Cord blood gas
  pH, mean (SD)226.99 (0.16)
  Base excess21−13.0 (6.0)
 Apgar scores27
  1 min3 (1–5)
  5 min5 (4–7)
  10 min7 (4–8)
 Need for respiratory support >10 min2722 (81.5%)
 HIE grade27
  I3 (11.1%)
  II15 (55.6%)
  III9 (33.3%)
 aEEG abnormality before TH27
 Normal2 (7.4%)
 Moderately abnormal21 (77.8%)
 Severely abnormal4 (14.8%)
 Cardiac compressions7 (25.9%)
 Resuscitation drugs1 (3.7%)
 Age active cooling commenced (hours)272.8 (1.3, 3.8)
 Temperature at start of active cooling (°C)2634.8 (1.18)
 Age when reached (hours) 33.5°C275.3 (4.2)
  • Values are n (%), mean (SD) or median (IQR) as appropriate.

  • *N denotes number of subjects for whom data were available.

  • †Pre-eclampsia, HELLP (haemolysis, elevated liver enzymes and a low platelet count) syndrome, pregnancy-induced hypertension, antepartum bleed, diabetes, Bell’s palsy and polyhydramnios.

  • ‡Cord prolapse, uterine rupture, shoulder dystocia, placental abruption, fetal decelerations, fetal bradycardia, prolonged rupture of membranes, reduced fetal movements, meconium-stained liquor.

  • aEEG, amplitude-integrated electroencephalogram; HIE, hypoxic–ischaemic encephalopathy; LNU, local neonatal unit; SCBU, special care baby unit; TH, therapeutic hypothermia.