Enhancing Nutrition and Antenatal Infection Treatment study outcomes
| PRIMARY OUTCOMES | |
| P1. Newborn weight | Weight of the unclothed infant measured at <72 hours of life. |
| P2. Newborn length | Infant length measured at <72 hours of life. |
| SECONDARY OUTCOMES | |
| S1. Gestational age | Gestational age determined by enrolment ultrasound, CRL used if <95 mm (INTERGROWTH 21st), then BPD/FL (WHO Kiserud) used if CRL >95 mm or missing. |
| S2a. Proportion of pregnancies resulting in delivery at <37 weeks gestation | Numerator: number of pregnancies resulting in spontaneous termination of pregnancy at <37 weeks gestation (including preterm live birth or fetal loss (spontaneous pregnancy loss, not due to induced abortion)). Denominator: All pregnancy outcomes. |
| S2b. Preterm live birth rate | Numerator: Live births <37 weeks of gestation. Denominator: Live births. |
| S3. Small-for-gestational age (INTERGROWTH) | Numerator: Infants <10% birth weight for GA by sex compared with INTERGROWTH neonatal birthweight standard.2 Denominator: Live births |
| S4. Low birth weight | Numerator: Newborns with birth weight (<72 hours of life) <2500 g. Denominator: Live births. We will also assess the outcome of birth weight <2000 g. |
| S5. Stillbirth rate | Numerator: Stillbirth/fetal death (≥28 weeks gestation) with no signs of life. Denominator: All live births and stillbirths |
| S6. Newborn head circumference | Head circumference of the infant measured at <72 hours of age. |
| S7. Newborn weight, length and head circumference for age Z-scores | Infant weight, length and head circumference for age z-scores measured at <72 hours of life, calculated using the INTERGROWTH neonatal standards for size at birth. |
| S8. Rate of weight gain in pregnancy | Maternal weight gain (kg) per week gestation in the second and third trimester. |
| S9. Maternal anaemia | Mean haemoglobin concentration in third trimester |
BPD, biparietal diameter; CRL, crown rump length; FL, femur length; GA, gestational age.