Table 5

Infants born at <32 weeks’ gestational age with a patent ductus arteriosus (PDA) who received treatment vs those who did not in England and Wales from 2010 to 2017

Infant characteristicsNot treatedTreatedP value for difference
n (%)10 791 (65.6)5721 (34.8)
Females, n (%)5056 (47.2)2635 (46.1)0.003
Gestational age at birth (weeks), median (IQR)27 (26–29)26 (24–27)<0.001
Birth weight (in g), mean (SD)1032 (327)851 (241)<0.001
Birth weight z-score, mean (SD)−0.14 (0.97)−0.17 (0.88)0.072
Length of stay (days), median (IQR)75 (51-96)97 (73-120)<0.001
Adverse outcomesNot treatedTreatedAdjusted OR (95% CI)*
Bronchopulmonary dysplasia, n (%)2948 (27.5)2519 (44.0)1.49 (1.39 to 1.60)†
Necrotising enterocolitis, n (%)784 (7.0)433 (7.6)0.73 (0.64 to 0.83)†
Late onset sepsis, n (%)5856 (54.6)4315 (75.4)1.64 (1.52 to 1.77)†
Death before discharge, n (%)1195 (11.1)709 (12.4)0.65 (0.58 to 0.73)†
  • *Adjusted for sex, gestation age and birthweightbirth weight z-score <-2SD.

  • †P<0.05 with Bonferroni correction.