Infant characteristics | Not treated | Treated | P value for difference |
n (%) | 5718 (54.9) | 4700 (45.1) | |
Females, n (%) | 2647 (46.3) | 2187 (46.5) | 0.807 |
Gestational age at birth (weeks), median (IQR) | 26 (25–27) | 25 (24–26) | <0.001 |
Birth weight (in g), mean (SD) | 837 (190) | 786 (174) | <0.001 |
Birth weight z-score, mean (SD) | −0.12 (0.87) | −0.13 (0.83) | 0.544 |
Length of stay (days), median (IQR) | 88 (69−110) | 103 (81−125) | <0.001 |
Adverse outcomes | Not treated | Treated | Adjusted OR (95% CI)* |
Bronchopulmonary dysplasia, n (%) | 2112 (36.9) | 2212 (47.1) | 1.42 (1.31 to 1.54)† |
Necrotising enterocolitis, n (%) | 578 (10.1) | 399 (8.5) | 0.72 (0.63 to 0.82)† |
Late onset sepsis, n (%) | 3847 (67.3) | 3702 (78.8) | 1.61 (1.47 to 1.76)† |
Death before discharge, n (%) | 974 (17.0) | 651 (13.9) | 0.59 (0.53 to 0.66)† |
*Adjusted for sex, gestation age and birth weight z-score <-2SD.
†P<0.05 with Bonferroni correction.
PDA, patent ductus arteriosus.