Table 7

Infants born at 28–31 weeks’ gestational age with a PDA who received treatment vs those who did not in England and Wales from 2010 to 2017

Infant characteristicsNot treatedTreatedP value for difference
n (%)5001 (83.0)1021 (17.0)
Females, n (%)2409 (48.2)448 (43.9)0.012
Gestational age at birth (weeks), median (IQR)29 (28−30)28 (28−29)<0.001
Birth weight (in g), mean (SD)1255 (306)1150 (278)<0.001
Birth weight z-score, mean (SD)−0.16 (1.07)−0.32 (1.07)<0.001
Length of stay (days), median (IQR)58 (45−73)68 (54−85)<0.001
Adverse outcomesNot treatedTreatedAdjusted OR (95% CI)*
Bronchopulmonary dysplasia, n (%)836 (16.7)307 (30.1)1.81 (1.54 to 2.13)†
Necrotising enterocolitis, n (%)170 (3.4)34 (3.3)0.83 (0.57 to 1.21)†
Late onset sepsis, n (%)1926 (38.5)555 (54.4)1.61 (1.40 to 1.86)†
Death before discharge, n (%)221 (4.4)58 (5.7)1.42 (1.05 to 1.90)†
  • *Adjusted for sex, gestation age and birth weight z-score <-2SD.

  • †P<0.05 with Bonferroni correction.

  • PDA, patent ductus arteriosus.