Data sources and variables or outcomes of interest
| Study design | Data source | Variables of interest | Years requested |
| Cohort study | North Thames Newborn Screening database (NBS) | Sex, date of birth, date of sample collection, ethnicity, birth weight, gestational age, screening test results, IMD (derived from postcode of residence at birth) | 2000–2020 |
| GOSH congenital hypothyroidism database (CH) | Final diagnosis, screening outcome, blood tests, thyroid scans, treatment doses, genotype | 2006–2020 | |
| Birth and Death Registration data | Date of death, cause of death, registration type, parents’ age, parents’ occupations, parent’s birth countries | 2000–2020 | |
| Follow-up study of cases and controls* | Hospital Episode Statistics (HES) | Hospital admissions, A&E attendances, outpatient visits (can be used to derive indicators of co-morbidity) | 2006–2020 |
| National Pupil Database (NPD) | EYFS results KS results Phonics tests SEN status Free school meal eligibility Language spoken | 2006–2020 | |
| NHS Business Services Authority community dispensing data (NHSBSA)† | Prescriptions submitted; prescriptions dispensed | 2006–2020 |
*The cases for the follow-up study will consist of the population in the CH database. Controls will be selected from pseudonymised HES data which are part of the Education and Child Health Insights from Linked Data linked database.
†NHSBSA will only be available for CH cases.
A&E, accident and emergency; EYFS, early years foundation stage; IMD, Index of Multiple Deprivation; KS, key stage; NHS, National Health Service; SEN, special educational needs.