Table 3

Diagnostic accuracy estimates as reported by the original publications, with 95% CI

	Barrio et al									Nicol et al									Nkereuwem et al
	Total	TP	FP	FN	TN	Sens		Spec		Total	TP	FP	FN	TN	Sens		Spec		Total	TP	FP	FN	TN	Sens		Spec
	(n)	(n)	(n)	(n)	(n)	%	95% CI	%	95% CI	(n)	(n)	(n)	(n)	(n)	%	95% CI	%	95% CI	(n)	(n)	(n)	(n)	(n)	%	95% CI	%	95% CI
Overall
MRS	79	3	5	2	69	60	17 to 93	95	73 to 100	204	35	10	49	110	41	32 to 52	92	85 to 95	415	40	55	23	297	65	44 to 85	84	77 to 89
CRS	73	6	2	49	22	11	5 to 23	92	72 to 99	204	44	1	121	38	26	21 to 34	97	87 to 100	415	58	37	118	202	33	25 to 42	83	72 to 92
HIV positive
MRS	–	–	–	–	–	–	–	–	–	40	15	1	10	14	60	41 to 77	93	70 to 99	61	8	11	7	35	55	29 to 82	76	62 to 87
CRS	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	61	14	5	30	12	32	18.9 to 47.0	71	47 to 92
HIV negative
MRS	–	–	–	–	–	–	–	–	–	164	20	9	39	96	34	23 to 47	91	85 to 95	344	31	40	15	258	68	42 to 88	86	79 to 91
CRS	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	344	43	28	86	187	33	24 to 44	86	76 to 92
Age										<2 years									<5 years
MRS	–	–	–	–	–	–	–	–	–	59	9	7	13	30	41	23 to 61	81	66 to 91	194	16	35	10	133	62	37 to 86	79	69 to 86
CRS	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	194	28	23	55	88	33	20 to 48	78	67 to 87
Age										>2 years									<5 years
MRS	–	–	–	–	–	–	–	–	–	145	26	3	36	80	42	30 to 54	96	90 to 99	221	24	20	13	164	67	40 to 90	89	82 to 94
CRS	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	–	221	30	14	63	114	33	22 to 44	88	76 to 96

CRS, composite reference standard; MRS, microbiological reference standard.