Table 1

Investigations recommended in children referred to secondary or tertiary care with short stature2 15 22

InvestigationTo detect or exclude
Full blood count (FBC)Anaemia*
Renal function (creatinine and electrolytes)Renal disorders
Liver function testLiver disease
Erythrocyte sedimentation rate (ESR)Infection/inflammatory disorders*
Calcium, phosphate (Ca/PO4) alkaline phosphatase (ALP)Renal/Ca/PO4 disorders
Tissue transglutaminase (TTG)Coeliac disease
Immunoglobulin A (IgA)Coeliac disease
Insulin-like growth factor-1 (IGF-1)Growth hormone deficiency
Free thyroxine (fT4), thyroid stimulating hormone (TSH)Hypothyroidism
Karyotype (or if not available Follicle Stimulating Hormone (FSH) if <2 or>9 year)†Turner syndrome
Bone ageAssess growth delay
Skeletal X-rays (if disproportion is present)Skeletal dysplasias
  • Panel of investigations proposed in international consensus statements from Oostdijk et al 2, Cohen et al 22 and Grote et al 15.

  • *To screen for coeliac disease/cystic fibrosis.

  • †Only in females.