Table 1

Interventions of interest

Drug regimenDoseDuration
Rifampin15 mg/kg/day (10–20 mg)3–4 months
Isoniazid with rifampin10 mg/kg/day (7–15 mg)
15 mg/kg/day (10–20 mg)
3–4 months
Rifapentine with
isoniazid
Rifapentine weekly dose:
300 mg (10–14 kg)
450 mg (14.1–25 kg)
600 mg (25.1–32 kg)
750 mg (32.1–50 kg)
900 mg (>50 kg)
3 months
Isoniazid weekly dose:
25 mg (2–11 years)
15 mg (≥12 years)
Isoniazid10 mg/kg/day (7–15 mg)6 months
Isoniazid10 mg/kg/day (7–15 mg)9 months
Isoniazid10 mg/kg/day (7–15 mg)12 months
Placebo
No treatment