Table 1

Summary of baseline characteristics, CSF isolates and microscopy, and hearing outcomes of the 16 neonates with definite meningitis

Birth gestational age, completed weeks28 (24–41; 25–38)
Birth weight, grammes935 (589–3630; 740–2280)
Postnatal age at diagnosis, days14 (2–89; 8–40)
Isolate, n cases:
Escherichia coli5
 Group B Streptococcus5
 Coagulase-negative Staphylococcus3*
Pseudomonas aeruginosa1
Enterobacter cloacae complex1
Candida albicans1
CSF cell counts
 WCC, x106/L745 (6–7420; 78–3015)
 % polymorphs of total WCC75% (0%–95%; 40%–90%)
 RCC, x106/L2525 (2–21 600; 540–6520)
 CSF ratio WCC:RCC1:4 (1:550 –1:6×10–4; 1:135–1:0.32)
Hearing outcomes†, n
 Sensorineural hearing loss2
 Normal3
 Satisfactory‡5
 N/A6
  • Data are median (range; IQR).

  • *1 Staphylococcus haemolyticus 1 Staphylococcus epidermidis, 1 not further speciated.

  • †Normal hearing ≤20 dB; mild hearing loss 21–40 dB minimum detectable threshold; moderate 41–70 dB; severe loss 71-95 dB; profound loss >95 dB.

  • ‡Satisfactory hearing, based on otoacoustic emissions and visual reinforcement audiometry with sound field testing down to 25 dB (no audiogram), but unable to rule out mild loss (n=3) or based on tone pip auditory brainstem responses/otoacoustic emissions (no audiogram) (n=2).

  • CSF, cerebrospinal fluid; N/A, not available; RCC, red cell count; WCC, white cell count.