Characteristics of the studies, pharmacokinetics and dose recommendations related to theophylline
| Study | n | PNA | Weight | Study design | Group | Model | Modality | Administered dose | Vd | CL | t1/2 (hours) | Recommended dose |
| Mulla et al,37 UK | N: 38 I: 14 | 8.4±5.9 for neonates 122±107 for infants | 3.3±0.5 for neonates 4.8±2.0 for infants | R 1 group compared with the literature | Children | 1-compartment with first-order elimination with WinNonMix Professional | VV–VA | 9.2±2.6 µg/kg/min infusion | The interindividual variability ↑40% | The interindividual variability ↓38% | — | Maintenance infusion rates following an initial loading dose (0.57×weight (kg)×10 mg/L). Maintenance infusion rate calculated from: average steady-state concentration=rate of infusion/clearance (using clearance parameters determined in the final model). |
Boldfaced fonts represent comparisons with controls within the same study. In other studies, they represent comparisons with non-ECMO neonates from a different published study.
CL, clearance; ECMO, extracorporeal membrane oxygenation; I, infants; N, neonates; PNA, postnatal age; R, retrospective; t1/2, elimination half-life; VA, veno-arterial; Vd, volume of distribution; VV, veno-venous.