NE use and NE response in neonates with dopamine-resistant shock
| All subjects | PPHN | Septic shock | |||||||
| Preterm (n=70) | Full term (n=22) | P value | Preterm (n=10) | Full term (n=14) | P value | Preterm (n=70) | Full term (n=22) | P value | |
| NE use | |||||||||
| Hours after shock | 7.0 (2.0–20.4) | 7.5 (4.0–18.2) | 0.84 | 15.5 (11.9–30.5) | 8.2 (4.5–15.0) | 0.06 | 5.0 (1.5–16.2) | 7.5 (1.8–16.2) | 0.84 |
| Max dosage (μg/kg/min) | 0.5 (0.3–1.0) | 0.5 (0.4–1.0) | 0.39 | 1.0 (0.6–1.3) | 0.6 (0.5–1.0) | 0.35 | 0.4 (0.2–0.8) | 0.4 (0.4–0.6) | 0.54 |
| Duration (hours) | 48 (26–88) | 39 (21–65) | 0.46 | 115 (89–140) | 38 (20–65) | 0.007 | 43 (24–72) | 42 (24–48) | 0.78 |
| NE response at 8 hours* | |||||||||
| Ventilation parameter | |||||||||
| FiO2 (%) | 0 (−10 to 4) (67) | 0 (−22 to 0) | 0.20 | −5 (–25 to 0) | 0 (−11 to 0) | 0.39 | 0 (−10 to 10) (51) | −5 (−24 to −1) | 0.16 |
| MAP (cmH2O) | 0 (−2 to 1) (18) | 0 (−2 to 0) (3) | 0.84 | −2 (−4 to 0) (6) | 0 (0–0) (2) | 0.39 | 0 (−2 to 1) (11) | −3 (−3 to −3) (1) | 0.31 |
| PIP (cmH2O) | 0 (−2 to 2) (48) | 0 (−2 to 0) (16) | 0.18 | −2 (−2 to −1) (4) | 0 (–2–0) (11) | 0.63 | 0 (−2 to 2) (39) | 0 (−2 to 0) (4) | 0.65 |
| PEEP (cmH2O) | 0 (0–0) (48) | 0 (0–0) (16) | 0.80 | 0 (0–0) (4) | 0 (0–0) (11) | 0.85 | 0 (0–0) (39) | 1 (0–1) (4) | 0.10 |
| Hemodynamics | |||||||||
| Heart rate (SDS) | −0.5 (−1.6 to 0.4) (68) | 0.0 (−0.5 to 0.4) (21) | 0.16 | −0.1 (–0.3 to 0.7) | 0.0 (–0.5 to 0.5) (13) | 0.98 | −0.8 (–1.7 to 0.1) (52) | −0.3 (–0.8 to 0.1) | 0.45 |
| SBP (SDS) | 0.8 (0.2–1.7) (26) | 1 (−0.5 to 2.9) (4) | 0.98 | 1.9 (1–2) (3) | 0.1 (–1.1 to 1.0) (3) | 0.20 | 0.7 (0.3–1.4) (21) | 5.9 (5.9–5.9) (1) | 0.09 |
| MBP (SDS) | 1.3 (0.6–2.0) (67) | 1.2 (0.6–2.0) | 0.89 | 1.7 (1.1–2.1) | 1.5 (0.6–1.8) | 0.47 | 1.3 (0.7–2.0) (51) | 1.6 (1.2–2.9) | 0.26 |
| Urine output (mL/kg/hour) | 1.1 (0.0–2.5) (37) | 1.5 (1.0–2.5) (15) | 0.44 | 0.0 (0.0–1.9) (5) | 1.4 (0.2–2.4) (10) | 0.54 | 1.5 (0–3.2) (28) | 2.0 (1.5–2.5) (5) | 0.56 |
| Artery blood gas | |||||||||
| pH | 0.09 (0.02–0.21) (69) | 0.08 (0.04–0.15) | 0.58 | 0.10 (0.04–0.12) | 0.08 (0.04–0.16) | 0.75 | 0.08 (0.02–0.19) | 0.04 (0.03–0.09) | 0.45 |
| pO2 (mm Hg) | 4 (−9 to 17) (69) | 10 (−3 to 16) | 0.57 | 4 (−2 to 13) | 10 (3–14) | 0.50 | 4 (−10 to 18) | 2 (−20 to 23) | 0.90 |
| pCO2 (mm Hg) | −6 (–13 to 0) (69) | −11 (−19 to −4) | 0.20 | −12 (−13 to −9) | −11 (−19 to −8) | 0.95 | −4 (−12 to 1) | −8 (−11 to −4) | 0.36 |
| Base excess (mmol/L) | 3.2 (0.0–7.4) (69) | 1.2 (−1.4 to 3.2) | 0.07 | 1.9 (−0.1 to 9.3) | 1.2 (−2.4 to 3.1) | 0.36 | 3.3 (0.8–6.5) | 1.0 (0.1–2.6) | 0.36 |
Data are presented in median (IQR) or percentage with number of available data in square brackets.
*Results are shown as change in parameters.
FiO2, fraction of inspired oxygen; MAP, mean airway pressure; MBP, mean blood pressure; NE, norepinephrine; PEEP, positive end-expiratory pressure; PIP, peak inspiratory pressure; PPHN, persistent pulmonary hypertension of the newborn; SBP, systolic blood pressure; SDS, SD score.