Significant predictors of mortality in neonates treated with NE using stepwise multiple linear regression
| Preterm neonates | Full term neonates | All neonates | ||||||
| Predictor | Beta | R2 | Predictor | Beta | R2 | Predictor | Beta | R2 |
| All subjects | ||||||||
| n=70 | 0.69 | n=22 | 0.99 | n=92 | 0.50 | |||
| NS | Epinephrine before NE | +1.265** | 0.70 | BE after NE | −0.022** | 0.21 | ||
| PPHN | ||||||||
| n=10 | 0.99 | n=14 | 0.99 | n=24 | 0.99 | |||
| Apgar score at 5 min | −0.161*** | 0.41 | pO2 after NE | −0.013*** | 0.51 | pO2 after NE | −0.010** | 0.28 |
| CRRT | +0.914*** | 0.25 | CRRT | +0.338*** | 0.22 | Gestational weeks | −0.163** | 0.23 |
| Change in pCO2 by 8 hours of NE | −0.062** | 0.21 | ||||||
| Septic shock | ||||||||
| n=54 | 0.60 | n=6 | n=60 | 0.52 | ||||
| Change in FiO2 by 8 hours of NE | +0.015*** | 0.28 | NA | Change in FiO2 by 8 hours of NE | +0.012*** | 0.21 | ||
Results are presented in β coefficient and R2 value of steady multivariate linear model after stepwise regression. R2 values are shown for each dependent variable (bold text, only variables with R2 are shown) and overall model (regular text). In β coefficient: Positive sign (‘+’) suggests increase in variable is associated with mortality; negative sign (‘−’) suggests decrease is associated with mortality.
Significance level: *p<0.05, **p<0.01, ***p<0.001.
BE, base excess; CRRT, continuous renal replacement therapy; FiO2, fraction of inspired oxygen; NA, not available (due to limited number of subjects); NE, norepinephrine; NS, not significant (results); PPHN, persistent pulmonary hypertension of the newborn;