Table 3

Significant predictors of mortality in neonates treated with NE using stepwise multiple linear regression

Preterm neonatesFull term neonatesAll neonates
All subjects
 NSEpinephrine before NE+1.265**0.70BE after NE0.022**0.21
Apgar score at 5 min0.161***0.41pO2 after NE0.013***0.51pO2 after NE0.010**0.28
CRRT+0.914***0.25CRRT+0.338***0.22Gestational weeks0.163**0.23
Change in pCO2 by 8 hours of NE0.062**0.21
Septic shock
Change in FiO2 by 8 hours of NE+0.015***0.28NAChange in FiO2 by 8 hours of NE+0.012***0.21
  • Results are presented in β coefficient and R2 value of steady multivariate linear model after stepwise regression. R2 values are shown for each dependent variable (bold text, only variables with R2 are shown) and overall model (regular text). In β coefficient: Positive sign (‘+’) suggests increase in variable is associated with mortality; negative sign (‘−’) suggests decrease is associated with mortality.

  • Significance level: *p<0.05, **p<0.01, ***p<0.001.

  • BE, base excess; CRRT, continuous renal replacement therapy; FiO2, fraction of inspired oxygen; NA, not available (due to limited number of subjects); NE, norepinephrine; NS, not significant (results); PPHN, persistent pulmonary hypertension of the newborn;