Table 1

Case fatality rates of COVID-19 and other vaccine-preventable diseases in children and adolescents

Disease or pathogenAge groupCase fatality rate (per 1000)
COVID-193*<1 year
1–4 years
5–11 years
12–15 years
15–19 years
0.017
0.003
0.003
0.009
0.015
Invasive pneumococcal disease104<5 years450 (210–620)†‡
Pertussis105<6 months
All ages (including adults)
72.0 (36.0–118)§
55.0 (33.0–61.0)§
Influenza106<5 years29.6 (7.9–51.3)§ (LMICs)
1.7 (0.8–2.6)§ (HICs)
Respiratory syncytial virus107<1 year
<1 year, preterm
2 years
<5 years
6.6 (1.9–16.9)‡
1.0 (0.2–12.1)‡
4.7 (1.2–14.7)‡
6.2 (2.6–13.7)‡
  • *Due to the relatively low proportion of COVID-19 cases in children that are tested in all settings, limited data from low-income and middle-income countries, and higher case fatality rates reported early in the pandemic, mortality estimates are presented from a national study in England.

  • †Severe disease only.

  • ‡Credible interval.

  • §Confidence interval.

  • HICs, high-income countries; LIMCs, low-income and middle-income countries.