Table 2

Comparison of in-hospital neonatal morbidities and interventions between periods

	Period 1 n=1479		Period 2 n=1839		P value
	n/N	%	n/N	%	P value
RDS*	1084/1477	73.4	1446/1801	81.4	<0.001
PDA	793/1477	53.7	1081/1797	60.2	<0.001
CLD on day 28	841/1475	57.0	1315/1689	77.9	<0.001
CLD at 36 weeks	477/1475	32.3	866/1656	52.3	<0.001
NEC and/or intestinal perforation	113/1479	7.6	185/1839	10.1	0.017
Sepsis	333/1477	22.5	445/1800	24.7	0.149
Early-onset sepsis	71/1477	4.8	132/1795	7.4	0.003
IVH (grades 3–4)	266/1450	18.3	244/1801	13.5	<0.001
Cystic periventricular leukomalacia	55/1477	3.7	46/1796	2.6	0.067
Received surfactant†	1160/1477	78.5	1538/1802	85.3	<0.001
PDA indomethacin for prophylaxis	36/1477	2.4	283/1796	15.8	<0.001
PDA treated with indomethacin	816/1477	55.2	1057/1796	58.9	0.040
PDA ligation	193/1473	13.1	362/1471	24.6	<0.001
LCC treated with steroids	244/1477	16.5	418/1789	23.4	<0.001
CLD treated with steroids	368/1475	24.9	613/1672	36.7	<0.001
Received antibiotics	1184/1477	80.2	1611/1786	90.2	<0.001
Retinopathy of prematurity, treated	442/1475	30.0	717/1650	43.5	<0.001
Parenteral nutrition	836/1477	56.6	1496/1812	82.6	<0.001
Home oxygen therapy at discharge	172/1475	11.7	349/1619	21.6	<0.001

*RDS was diagnosed by clinical and radiographic findings with or without a stable microbubble test.
†Received surfactant represents surfactant given during the acute phase of respiratory difficulties.
CLD, chronic lung disease; IVH, intraventricular haemorrhage; LCC, late-onset circulatory collapse; NEC, necrotising enterocolitis; n/N, number/number of evaluations; PDA, patent ductus arteriosus; RDS, respiratory distress syndrome.