Table 3

Clinical and nutritional correlates of likely Escherichia coli encoding heat-stable ST-ETEC and Shigella aetiology of diarrhoea among children aged 2–23 months with moderate-to-severe diarrhoea adjusted for factors

Escherichia coli encoding heat-stable toxin aetiologyShigella aetiology
Proportion n/N (%)Adjusted* OR (95% CI)P valueProportion n/N (%)Adjusted* OR (95% CI)P value
Moderate to severe diarrhoea defining characteristics
Severe stunting only40/417 (9.6)Ref.52/417 (12.5)Ref.
Some/severe dehydration only378/2815 (13.4)1.74 (1.19, 2.62)0.006305/2832 (10.8)1.18 (0.82 to 1.73)0.38
MAM only319/2227 (14.3)1.69 (1.15 o to 2.53)0.009320/2224 (14.4)1.29 (0.90 to 1.86)0.17
MAM and some/severe dehydration81/623 (13.0)1.83 (1.18 to 2.89)0.00890/626 (14.4)1.64 (1.09 to 2.50)0.02
MAM and severe stunting45/408 (11.0)1.04 (0.62 to 1.74)0.8763/408 (15.4)1.08 (0.69 to 1.70)0.75
Some/severe dehydration and severe stunting14/95 (14.7)1.92 (0.92 to 3.82)0.075/95 (5.3)0.52 (0.17 to 1.27)0.19
MAM, some/severe dehydration and severe stunting12/84 (14.3)1.19 (0.46 to 2.71)0.6910/84 (11.9)0.68 (0.25, 1.58)0.41
Fever
No767/5865 (13.1)Ref736/5883 (12.5)Ref
Yes122/806 (15.1)1.12 (0.89 to 1.40)0.31109/808 (13.5)1.15 (0.90 to 1.46)0.26
Duration of diarrhoea (excluding day of enrolment)
Diarrhoea (0–6 days)846/6308 (13.4)Ref783/6327 (12.4)Ref
Prolonged duration (7–14 days)43/363 (11.8)1.05 (0.72 to 1.50)0.7962/364 (17.0)1.29 (0.92 to 1.78)0.13
Frequency of diarrhoea in the past 24 hours
Low frequency (3–6 stools)433/3521 (12.3)Ref406/3535 (11.5)Ref
High frequency (>6 loose stools)456/3150 (14.5)1.10 (0.93 to 1.31)0.28439/3156 (13.9)1.17 (0.98 to 1.40)0.08
  • *Adjusted for child age, child sex, household wealth quintile, maternal age, maternal education, country of enrolment, rotavirus vaccination status, maternal BMI, total number of children under age 5 year in the household, defining characteristic of moderate to severe diarrhoea, fever, duration of diarrhoea and high versus low frequency of stools in past 24 hours.

  • BMI, body mass index; MAM, moderate acute malnutrition; ST-ETEC, stable toxin-enterotoxigenic Escherichia coli.