Studies | Antacids | Control | P values* |
Corvaglia et al 12 | |||
Total GORs | 49.00 (28.50–67.00) | 58.50 (33.50–75.75) | 0.024 |
Liquid GORs | 21.50 (12.25–32.00) | 21.50 (13.50–39.75) | 0.432 |
Gaseous GORs | 2.00 (0.25–7.50) | 3.00 (0.00–14.75) | 0.040 |
Mixed GORs | 3.00 (2.00–5.75) | 3.00 (1.00–5.00) | 0.614 |
pH-GORs | 17.00 (6.00–29.75 | 29.00 (13.50–44.50) | 0.002 |
aMII-GORs | 4.00 (2.00–8.25) | 6.00 (2.25–11.75) | 0.050 |
NaMII-GORs | 19.00 (10.00–32.75) | 18.50 (8.50–33.75) | 0.743 |
RIpH | 4.0 (1.8–13.1) | 7.6 (3.3–17.0) | 0.030 |
aMII-GOR-BEI | 0.2 (0.1–0.6) | 0.4 (0.1–1.0) | 0.036 |
NaMII-GOR-BEI | 1.2 (0.5–1.9) | 0.9 (0.5–1.7) | 0.822 |
Distal GORs (no.) | 18.00 (11.25–27.00 | 15.00 (9.25–26.00) | 0.959 |
Proximal GORs (no.) | 5.50 (4.00–9.00) | 7.50 (3.00–12.00) | 0.030 |
Corvaglia et al 13 | |||
Total GOR episodes | 9 (0–33) | 20.5 (1–42) | 0.001 |
pH-GOR | 2 (0–26) | 7.5 (0–23) | 0.004 |
aMII-GOR | 1 (0–5) | 3 (0–16) | 0.001 |
NaMII-GOR | 4.5 (0–22) | 6 (1–21) | 0.145 |
RIpH | 0.9 (0–23.2) | 8.4 (0–44.2) | 0.001 |
aMII-BEI | 0.17 (0–2) | 0.5 (0–8.1) | 0.002 |
NaMII-BEI | 0.75 (0–5.7) | 1.0 (0.1–9.2) | 0.982 |
Total apnoea episodes | 9.5 (0–35) | 9.5 (0–44) | 0.99 |
Central apnoeas | 3.5 (0–25) | 5 (0–34) | 0.22 |
Obstructive apnoeas | 1 (0–8) | 1 (0–10) | 0.10 |
Mixed apnoeas | 3 (0–16) | 4 (0–17) | 0.98 |
Desaturations | 0.5 (0–10) | 0 (0–12) | 0.41 |
Bradycardia | 0 (0–3) | 0 (0–3) | 0.32 |
Pathological apnoeas | 0 (0–5) | 0 (0–7) | 0.69 |
Values are reported as median (IQR).
*P values as provided in the original publication. The level of significance was set at p≤0.05.
aMII-GOR, acid GOR episode detected by MII; aMII-GOR-BEI, acid MII-GOR-bolus exposure index; GOR, gastro-oesophageal reflux; MII, multichannel intraluminal impedance monitoring; NaMII-GOR, non-acid GOR episode detected by MII; NaMII-GOR-BEI, non-acid MII-GOR-bolus exposure index; pH-GOR, GOR episodes detected only by pH monitoring; RIpH, reflux index detected only by pH monitoring.