Time window period (days) | No. of exposed in hazard period (n=161 386) N (%) | No. of exposed in control period (n=645 544) N (%) | Crude | Adjusted | ||||||
OR (95% CI)* | P value | OR (95% CI)† | P value | |||||||
3 | 9773 | (6.06) | 38 276 | (5.93) | 1.04 | (1.01 to 1.08) | 0.0090 | 1.28 | (1.24 to 1.32) | <0.0001 |
7 | 12 673 | (7.85) | 48 882 | (7.57) | 1.07 | (1.04 to 1.09) | <0.0001 | 1.29 | (1.26 to 1.33) | <0.0001 |
14 | 17 080 | (10.58) | 63 578 | (9.85) | 1.13 | (1.10 to 1.15) | <0.0001 | 1.34 | (1.31 to 1.37) | <0.0001 |
28 | 24 568 | (15.22) | 87 991 | (13.63) | 1.20 | (1.18 to 1.22) | <0.0001 | 1.38 | (1.36 to 1.41) | <0.0001 |
56 | 35 969 | (22.29) | 135 123 | (20.93) | 1.11 | (1.10 to 1.13) | <0.0001 | 1.21 | (1.19 to 1.22) | <0.0001 |
*Calculated by conditional logistic regression.
†Calculated by conditional logistic regression adjusted for concomitant medications.