Characteristics of the external validation cohort (NeoOBS-SA study) compared with the internal validation cohort (NeoHoP study)16
| External validation cohort | Internal validation cohort | Univariate p value | |||
| Baseline characteristics | |||||
| n | 346 | 406 | |||
| Gestational age (weeks), median (IQR) | 30 | (28–34) | 28 | (27–30) | <0.001 |
| Birth weight (g), median (IQR) | 1270 | (990–1845) | 1010 | (850–1178) | <0.001 |
| VLBW infants, <1500 g, n (%) | 222 | (64.2) | 406 | (100.0) | <0.001 |
| Male, n (%) | 188 | (54.3) | 193 | (47.5) | 0.063 |
| Born in a healthcare facility, n (%) | 272 | (78.6) | 369 | (90.9) | <0.001 |
| Vaginal birth, n (%) | 142/331 | (42.9) | 197 | (35.6) | 0.128 |
| Born to mother living with HIV, n (%) | 115/344 | (33.4) | 120 | (29.6) | 0.255 |
| Characteristics of HAI episodes | |||||
| n | 573 | 552 | |||
| No HAI, n (%) | 105 | (18.3) | 337 | (61.1) | <0.001 |
| Any HAI, n (%) | 468 | (81.7) | 215 | (38.9) | <0.001 |
| Presumed HAI | 282 | (60.3) | 106 | (49.3) | 0.008 |
| Proven HAI | 186 | (39.7) | 109 | (50.7) | 0.008 |
| Gram-negative | 100 | (53.8) | 56 | (51.4) | 0.157 |
| Gram-positive | 41 | (22.0) | 35 | (32.1) | 0.056 |
| Fungi | 23 | (12.4) | 2 | (1.8) | <0.001 |
| Polymicrobial | 22 | (11.8) | 16 | (14.7) | 0.481 |
HAI, healthcare-associated infection; NeoHoP, Neonatal Healthcare-associated infectiOn Prediction; NeoOBS, Neonatal Sepsis Observational study; VLBW, very low birth weight.