Abstract
We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis duringl-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins.l-asparaginase induced coagulopathy may cause osteonecrosis.
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Abbreviations
- ALL:
-
acute lymphocytic leukaemia
- APTT:
-
activated partial thromboplastin time
- AT-III:
-
antithrombin III
- FDP:
-
fibrin/fibrinogen degradation products
- l-ASP:
-
l-asparaginase
- MRI:
-
magnetic resonance imaging
- PT:
-
prothrombin time
References
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Hanada, T., Horigome, Y., Inudoh, M. et al. Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia duringl-asparaginase therapy. Eur J Pediatr 149, 162–163 (1989). https://doi.org/10.1007/BF01958270
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DOI: https://doi.org/10.1007/BF01958270