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Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia duringl-asparaginase therapy

  • Hematology/Oncology
  • Published:
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Abstract

We report a child with acute lymphocytic leukaemia who developed simultaneous osteonecrosis of vertebrae and cerebral thrombosis duringl-asparaginase therapy. Fibrinogen, antithrombin III and plasminogen were decreased. Fresh frozen plasma in addition to antithrombin III concentrates were used to replenish these haemostatic proteins.l-asparaginase induced coagulopathy may cause osteonecrosis.

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Abbreviations

ALL:

acute lymphocytic leukaemia

APTT:

activated partial thromboplastin time

AT-III:

antithrombin III

FDP:

fibrin/fibrinogen degradation products

l-ASP:

l-asparaginase

MRI:

magnetic resonance imaging

PT:

prothrombin time

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Hanada, T., Horigome, Y., Inudoh, M. et al. Osteonecrosis of vertebrae in a child with acute lymphocytic leukaemia duringl-asparaginase therapy. Eur J Pediatr 149, 162–163 (1989). https://doi.org/10.1007/BF01958270

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  • DOI: https://doi.org/10.1007/BF01958270

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