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Defining recovery in chronic fatigue syndrome: a critical review

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Abstract

Purpose

In chronic fatigue syndrome (CFS), the lack of consensus on how recovery should be defined or interpreted has generated controversy and confusion. The purpose of this paper was to systematically review, compare, and evaluate the definitions of recovery reported in the CFS literature and to make recommendations about the scope of recovery assessments.

Methods

A search was done using the MEDLINE, PubMed, PsycINFO, CINAHL, and Cochrane databases for peer review papers that contained the search terms “chronic fatigue syndrome” and “recovery,” “reversal,” “remission,” and/or “treatment response.”

Results

From the 22 extracted studies, recovery was operationally defined by reference with one or more of these domains: (1) pre-morbid functioning; (2) both fatigue and function; (3) fatigue (or related symptoms) alone; (4) function alone; and/or (5) brief global assessment. Almost all of the studies measuring recovery in CFS did so differently. The brief global assessment was the most common outcome measure used to define recovery. Estimates of recovery ranged from 0 to 66 % in intervention studies and 2.6 to 62 % in naturalistic studies.

Conclusions

Given that the term “recovery” was often based on limited assessments and less than full restoration of health, other more precise and accurate labels (e.g., clinically significant improvement) may be more appropriate and informative. In keeping with common understandings of the term recovery, we recommend a consistent definition that captures a broad-based return to health with assessments of both fatigue and function as well as the patient’s perceptions of his/her recovery status.

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Acknowledgments

We thank Stefan Schneider, PhD for his helpful comments on the manuscript.

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Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Stony Brook University, Putnam Hall/South Campus, Stony Brook, NY, 11794-8790, USA

    Jenna L. Adamowicz, Indre Caikauskaite & Fred Friedberg

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  1. Jenna L. Adamowicz
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Correspondence to Jenna L. Adamowicz.

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Adamowicz, J.L., Caikauskaite, I. & Friedberg, F. Defining recovery in chronic fatigue syndrome: a critical review. Qual Life Res 23, 2407–2416 (2014). https://doi.org/10.1007/s11136-014-0705-9

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