Therapeutic reviewPharmacokinetics of topically applied ophthalmic drugs
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2023, OphthalmologyCitation Excerpt :The problem of eye dropper medication waste is compounded for those with difficulty instilling eye drops. One study showed that, for every 1 drop properly instilled by a patient, 7 drops are wasted during the instillation attempt.1 Smaller-volume eye drops allow for greater administrative precision, which is particularly useful for pediatric patients who have difficulty with receiving eye drops.
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2022, Experimental Eye ResearchCitation Excerpt :Smaller drop volumes may also result in a cost-saving for patients, as, in theory, fewer bottles of eye drops would be needed if no changes were made to the total volume of the drop bottles manufactured (Karki et al., 2011). The commonest form of topical ocular drug is aqueous solution eye drops, where all ingredients are completely dissolved within the solution (Shell, 1982). A pulse of drug delivery is achieved after the instillation, with subsequent rapid decline in drug concentration, with a kinetic profile similar to first order elimination (Souto et al., 2019).
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