Brief clinical and laboratory observationIntraventricular hemorrhage following volume expansion after hypovolemic hypotension in the newborn beagle+
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Moderate, rapidly induced hypertension as a cause of intraventricular hemorrhage in the newborn beagle model
J Pediatr
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The association of rapid volume expansion and intraventricular hemorrhage in the preterm infant
J Pediatr
(1980) Failure of autoregulation and intraventricular haemorrhage in preterm infants
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Cited by (88)
Brain Injury in the Preterm Infant
2023, Avery's Diseases of the NewbornPeriventricular- intraventricular hemorrhage in the premature infant- A historical perspective
2022, Seminars in PerinatologyCitation Excerpt :First, the cerebral circulation of the sick infant was shown to be pressure passive (see above).16,17,20-22 Second, in a beagle puppy model, GMH could be produced by induced systemic hypertension with or without prior hypotension.25,26 Third, infants with lower mean ABP in the first postnatal days as well infants who received rapid volume expansion to correct hypotension were more likely to develop IVH.27,28
Monitoring and management of brain hemodynamics and oxygenation
2019, Handbook of Clinical NeurologyCitation Excerpt :Although there were differences in sample size and NIRS devices used in these studies, there is not a consistent difference in methodologies that easily explains the opposite results regarding CrSO2 and FTOE changes with IVH. An increase in CrSO2 could be related to increased cerebral blood flow in association with developing GM/IVH, as ischemia/reperfusion is a known pathogenetic mechanism for GM-IVH from animal data (Goddard-Finegold et al., 1982). A small study of preterm newborns supports this mechanism, as newborns who developed IVH had lower left ventricular output (LVO) followed by an increase in LVO and CBF velocity in the hours just prior to the detection of IVH by US (Noori et al., 2014).
Optimal Mean Arterial Blood Pressure in Extremely Preterm Infants within the First 24 Hours of Life
2018, Journal of PediatricsIntraventricular Hemorrhage and White Matter Injury in the Preterm Infant
2018, Neurology: Neonatology Questions and ControversiesPreterm Intraventricular Hemorrhage/Posthemorrhagic Hydrocephalus
2018, Volpe's Neurology of the Newborn
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Supported by Baylor College of Medicine Biomedical Research Support Grant No. 520-9100 and by the Departments of Pediatrics and Pediatric Pathology of the Texas Children's Hospital