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Interrupted BCG vaccination is a major threat to global child health

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Cited by (27)

  • Management of Children with Tuberculosis

    2019, Clinics in Chest Medicine
    Citation Excerpt :

    In practice, this risk is minimized by well-functioning prevention of mother to child (vertical) HIV transmission programs. It is important to ensure high BCG coverage rates in all settings with uncontrolled TB transmission.23 Countries with minimal TB transmission, like the United States, often do not provide BCG vaccination at birth.

  • MTBVAC-Based TB-HIV Vaccine Is Safe, Elicits HIV-T Cell Responses, and Protects against Mycobacterium tuberculosis in Mice

    2019, Molecular Therapy Methods and Clinical Development
    Citation Excerpt :

    Nevertheless, BCG8 vaccination has several beneficial effects: (1) BCG vaccination reduces rates of Mycobacterium tuberculosis (Mtb) infection, aiding in the decrease of the pool of latent infections from which future cases of active disease may arise;9 (2) BCG provides strong protection against disseminated forms of the disease in infants and young children;10,11 (3) BCG revaccination of adolescents may provide additional benefits for the prevention of TB;12 and (4) BCG vaccination reduces all-cause mortality through beneficial non-specific (heterologous) effects on the immune system.13,14 These four effects strengthen the motivation for the inclusion of BCG in the global vaccination program.15 We previously constructed and characterized MTBVAC, the first and only live-attenuated Mtb-based vaccine candidate in clinical development against TB disease in the pipeline.

  • A Multistage Subunit Vaccine Effectively Protects Mice Against Primary Progressive Tuberculosis, Latency and Reactivation

    2017, EBioMedicine
    Citation Excerpt :

    Because the protection against primary infection induced by repeat BCG vaccination was inferior to that induced by BCG vaccination alone (Cruz et al., 2010), two- or multistage subunit vaccines might be a suitable replacement of BCG to prevent against primary infection in adults. BCG has been integrated into the Expanded Immunization Program of WHO since 1974 and neonatal vaccination with BCG is still used to prevent TB in countries with a high burden of TB (Marais et al., 2016). Correspondingly, adolescents and adults with LTBI always occur epidemiologically following inoculation with BCG after birth.

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