Editor’s Capsule Summary
What is already known on this topic
Recently, the Food and Drug Administration issued a warning that ondansetron may induce fatal arrhythmias, leading to concerns about emergency department use.
What question this study addressed
This systematic review analyzed available sources to identify cases of arrhythmia temporally associated with the administration of a single oral ondansetron dose. A secondary outcome was identifying all cases associating ondansetron administration to an arrhythmia.
What this study adds to our knowledge
No reports describing an arrhythmia associated with single oral ondansetron dose administration were identified.
How this is relevant to clinical practice
This study supports the safety of the clinical practice of administering a single oral ondansetron dose to low-risk patients without the need for screening evaluations.