Original Article
A taxonomy has been developed for outcomes in medical research to help improve knowledge discovery

https://doi.org/10.1016/j.jclinepi.2017.12.020Get rights and content
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Abstract

Objectives

There is increasing recognition that insufficient attention has been paid to the choice of outcomes measured in clinical trials. The lack of a standardized outcome classification system results in inconsistencies due to ambiguity and variation in how outcomes are described across different studies. Being able to classify by outcome would increase efficiency in searching sources such as clinical trial registries, patient registries, the Cochrane Database of Systematic Reviews, and the Core Outcome Measures in Effectiveness Trials (COMET) database of core outcome sets (COS), thus aiding knowledge discovery.

Study Design and Setting

A literature review was carried out to determine existing outcome classification systems, none of which were sufficiently comprehensive or granular for classification of all potential outcomes from clinical trials. A new taxonomy for outcome classification was developed, and as proof of principle, outcomes extracted from all published COS in the COMET database, selected Cochrane reviews, and clinical trial registry entries were classified using this new system.

Results

Application of this new taxonomy to COS in the COMET database revealed that 274/299 (92%) COS include at least one physiological outcome, whereas only 177 (59%) include at least one measure of impact (global quality of life or some measure of functioning) and only 105 (35%) made reference to adverse events.

Conclusions

This outcome taxonomy will be used to annotate outcomes included in COS within the COMET database and is currently being piloted for use in Cochrane Reviews within the Cochrane Linked Data Project. Wider implementation of this standard taxonomy in trial and systematic review databases and registries will further promote efficient searching, reporting, and classification of trial outcomes.

Keywords

Randomized controlled trials
Outcomes
Effectiveness trials
PICO
Taxonomy
COMET
Cochrane
Core outcome sets
Systematic reviews
Classification
Comparative effectiveness research

Cited by (0)

Funding: S.D. and P.R.W. are funded by MRC North West Hub for Trials Methodology Research MR/K025635/1. P.R.W. and M.C. are the members of the COMET Management Group.