Original ArticlePerinatal Events and Early Magnetic Resonance Imaging in Therapeutic Hypothermia
Section snippets
Methods
Neonates admitted to the intensive care nursery at University of California, San Fransisco (UCSF) were enrolled in an ongoing study to determine whether MRI findings can serve as a predictor of outcome following HIE from 2004 to present.
Our therapeutic hypothermia program started in November 2007. Institutional eligibility criteria for therapeutic hypothermia include the following: (1) birth at ≥ 36 weeks postmenstrual age; (2) the presence of one or more of the following: an APGAR score of
Results
Nontreated neonates had a higher encephalopathy score on the first day of life compared with those who were treated (5.5 versus 4, P = .0001) and were imaged, on average, 1 day earlier, day of life 4 (range, 2 to 7) versus day of life 5 (range, 4 to 9) (Table II). The neuromotor assessment at the time of MRI was similar between the two groups.
Discussion
Using conventional MRI with DWI early after cooling, we found that neonates treated with therapeutic hypothermia have less extensive injury and a have a higher rate of normal MRI when compared with a comparable historical cohort and that there is a differential effect of therapeutic hypothermia in babies who present with perinatal sentinel events as compared with those with a history of decreased fetal movements. Additionally, therapeutic hypothermia was protective for moderate-severe brain
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Cited by (0)
Supported by NIH/NCRR UCSF-CTSI (grant UL1 RR024131) and NIH (grant P50 NS035902-12). S.B. was supported by NIH (training grant 5T32HD007162), H.G. is supported by NINDS (1K23NS66137), and J.V. was supported by the APS/SPR Student Research Program. The contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH. Information on NCRR is available at http://www.ncrr.nih.gov/. Re-engineering the Clinical Research Enterprise can be obtained from http://nihroadmap.nih.gov/clinicalresearch/overview-translational.asp. The authors declare no conflicts of interest.