Original ArticleTransitional Changes in Cardiac and Cerebral Hemodynamics in Term Neonates at Birth
Section snippets
Methods
In this prospective observational study, we investigated the changes in cardiac function, CBF, cerebral regional oxygen saturation (rSO2) and SaO2 occurring immediately after birth and during transition in the first 48 hours of postnatal life in term infants. We also examined whether the anticipated change in CBF is associated with or independent of changes in cardiac function.
The Institutional Review Board at the Children’s Hospital of the University of Oklahoma Health Sciences Center approved
Results
Twenty term neonates (mean gestational age, 39.1 ± 1.3 weeks; mean birth weight, 3449 ± 392 g) were studied. The median (range) Apgar scores were 8 (7-9) at 1 minute and 9 (8-10) at 5 minutes. All neonates were appropriate for gestational age, and 55% were male. Racial distribution was 40% black, 35% white, 10% Hispanic, and 5% Asian. Complete data were collected in the delivery room for all subjects. The NIRS monitor displayed the rSO2 value within few seconds of sensor placement and often
Discussion
Our data show that our subjects experienced significant changes in cardiac function, cerebral hemodynamics, and oxygenation during the first 20 minutes after birth, and that smaller changes continued through the first 48 hours after birth. The initial rise in cerebral rSO2 during the first 8 minutes after birth most likely is related to increased blood oxygen content as a result of the increased SaO2. Subsequently, cerebral rSO2 decreased despite continued increases in SaO2 from 9 to 17
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Cited by (0)
Masimo Corporation and Somanetics (now Covidien) Corporation provided equipment support. The authors declare no conflicts of interest.