Original articleRetinal and Optic Nerve Hemorrhages in the Newborn Infant: One-Year Results of the Newborn Eye Screen Test Study
Section snippets
Study Design
The Newborn Eye Screen Testing (NEST) study was a prospective institutional cohort study conducted at Lucile Packard Children's Hospital (LPCH) at Stanford University School of Medicine. It was designed to determine the birth prevalence of ophthalmic disease and the long-term vision outcomes of newborns with ocular abnormalities identified at birth. Universal newborn screening with retinal image photography was offered to all infants born at LPCH who do not undergo retinopathy of prematurity
Eligible Study Population
During the 1-year study period, 830 newborns who met inclusion criteria for NEST study participation were approached. The approached study population was 53.7% male and included 33 sets of twins and 3 sets of triplets. Thirty-one percent of approached mothers self-identified as Hispanic or Latino, and self-identified race was reported as 52.2% white or Caucasian, 41.0% Asian, 4.3% Native Hawaiian or other Pacific Islander, and 2.6% African American or black. Study recruitment was performed in
Discussion
This article presents the 1-year results of the first universal retinal image screening performed in healthy term infants in the United States. The birth prevalence of FH among the newborns screened during the first year of enrollment in the NEST study at LPCH at Stanford University was 20.3% (41/202). The birth prevalence of multilaminar hemorrhages was 14.4% (29/202), and the birth prevalence of foveal hemorrhages was 3.0% (6/202). The rate of FH reported in this study is similar to that
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2021, American Journal of Ophthalmology Case ReportsCitation Excerpt :In addition, the birth trauma of vaginal delivery is thought to create an acute rise in intracranial pressure that leads to stasis of blood flow in the central retinal vein, which can cause acute changes in the pressure of the retinal vasculature and precipitate retinal capillary hemorrhage. 11,12 This concept is supported by the finding that vaginal delivery conferred substantially increased risk of fundus hemorrhages in healthy newborns in the Newborn Eye Screen Test (NEST) Study. 13 However, there were no cases of vitreous hemorrhage in the NEST cohort, nor in other large screening studies of healthy newborns 14–16.
What Is Left After Resolution of Neonatal Retinal Hemorrhage: The Longitudinal Long-term Outcome in Foveal Structure and Visual Function
2021, American Journal of OphthalmologyCitation Excerpt :In addition, the cone has achieved a parallel density to that of adults.19,20 Previous studies show that hemorrhage is located in the intra-retina via funduscopy or RetCam, but little is known about the microstructural changes in the retina.6,21 Spectral-domain OCT imaging in children is a new field that has expanded our understanding of the developing retina through longitudinal, in vivo analysis of the macular microstructure.11,17
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Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the Giannini Foundation (San Francisco, CA); and the Spectrum TL1 Clinical Research Training Program at Stanford University (Palo Alto, CA); supported by the National Institutes of Health (Bethesda, MD) (grant no.: TL1 TR 001084 [N.F.C., C.A.L.]). The sponsor or funding organization had no role in the design or conduct of this research. The database for the project described was supported by the National Center for Research Resources and the National Center for Advancing Translation Sciences, National Institutes of Health (grant no.: UL1 RR025744). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Author Contributions:
Conception and design: Callaway, Ludwig, Blumenkranz, Jones, Fredrick, Moshfeghi
Analysis and interpretation: Callaway, Ludwig, Blumenkranz, Jones, Fredrick, Moshfeghi
Data collection: Callaway, Ludwig, Blumenkranz, Jones, Fredrick, Moshfeghi
Obtained funding: Moshfeghi, Blumenkranz, Fredrick
Overall responsibility: Callaway, Ludwig, Blumenkranz, Jones, Fredrick, Moshfeghi