Fetus-Placenta-NewbornFetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years*,**
Section snippets
Study design
We examined the relationship between the occurrence of cerebral palsy at age 3 years and the presence of funisitis, amniotic fluid concentrations of interleukin 6 (IL-6) and interleukin 8 (IL-8), and amniotic fluid white blood cell count. The cohort consisted of patients who delivered preterm neonates at Seoul National University Hospital between January 1993 and December 1995 and who met the following criteria: (1) preterm singleton birth (gestational age at birth ≤35 weeks), (2)
Results
During the study period 340 women delivered singleton preterm newborns (gestational age at birth, 26-35 weeks). Among these, 172 underwent transabdominal amniocentesis, and cerebral palsy was subsequently diagnosed in 14 of their children. Among 168 patients who did not undergo amniocentesis, cerebral palsy was diagnosed in 6 of their children. There was no significant difference in the rate of cerebral palsy between patients who underwent amniocentesis and those who did not (8.1% [14/172] vs
Comment
Our data clearly demonstrate that amniotic fluid concentrations of specific cytokines (IL-6 and IL-8) and amniotic fluid white blood cell count are significantly higher in fetuses with subsequent development of cerebral palsy than in those without subsequent development of cerebral palsy, an association that remained significant after adjustment for gestational age at birth. Moreover, we report here that the presence of a systemic fetal inflammatory response (funisitis) is associated with both
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Cited by (0)
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Supported by grant 03-96-050 from Seoul National University Hospital Research Fund, grant of KISTEP (Korea Institute of Science & Technology Evaluation and Planning), and grant 97-04-03-08-01-3 from the Korea Science and Engineering Foundation.
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Reprint requests: Bo Hyun Yoon, MD, PhD, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, 110-744, Korea.