Abstract
Prednisolone has unknown growth-suppressing effects relative to other steroids. We retrospectively studied 9 children (6 with congenital adrenal hyperplasia, CAH) receiving hydrocortisone replacement after switching to prednisolone (dose ratio, 1:5). Growth velocity and, in patients with CAH, 17-OHP decreased significantly. Dose reduction reversed these effects. Roughly, growth suppression relative potency for prednisolone:hydrocortisone was 15:1.
MeSH terms
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Adrenal Hyperplasia, Congenital / drug therapy*
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Adrenal Insufficiency / drug therapy*
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Anti-Inflammatory Agents / adverse effects
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Anti-Inflammatory Agents / pharmacokinetics*
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Anti-Inflammatory Agents / therapeutic use*
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Child
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Child, Preschool
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Cohort Studies
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Dose-Response Relationship, Drug
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Female
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Growth Disorders / chemically induced*
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Humans
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Hydrocortisone / adverse effects
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Hydrocortisone / pharmacokinetics*
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Hydrocortisone / therapeutic use*
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Infant
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Male
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Prednisolone / adverse effects
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Prednisolone / pharmacokinetics*
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Prednisolone / therapeutic use*
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Retrospective Studies
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Therapeutic Equivalency
Substances
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Anti-Inflammatory Agents
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Prednisolone
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Hydrocortisone