IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure

T Asano; K Ichiki; S Koizumi; K Kaizu; T Hatori; O Fujino; K Mashiko; Y Sakamoto; T Miyasho; Y Fukunaga

doi:10.1111/j.1365-3083.2010.02391.x

IL-8 in cerebrospinal fluid from children with acute encephalopathy is higher than in that from children with febrile seizure

Scand J Immunol. 2010 Jun;71(6):447-51. doi: 10.1111/j.1365-3083.2010.02391.x.

Authors

T Asano¹, K Ichiki, S Koizumi, K Kaizu, T Hatori, O Fujino, K Mashiko, Y Sakamoto, T Miyasho, Y Fukunaga

Affiliation

¹ Department of Pediatrics, Nippon Medical School, Chiba-Hokusoh Hospital, Chiba-Pre., Japan. VFF13540@nifty.ne.jp

PMID: 20500697
DOI: 10.1111/j.1365-3083.2010.02391.x

Abstract

We identify possible differences in the cytokine/chemokine profiles in cerebrospinal fluid (CSF) from children with encephalopathy and febrile seizure. Interleukin (IL)-1beta, 2, 4, 5, 6, 7, 8, 10, 12, 13, 17, interferon-gamma, tumour necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta were measured simultaneously in CSF supernatants from children with encephalopathy (n = 8), febrile seizure (n = 16) and fever without neurological complications (n = 8). IL-8 in CSF from children with encephalopathy was significantly elevated compared to that in CSF from children with febrile seizure and fever without neurological complications. IL-8 in CSF was also higher than serum IL-8, suggesting that increased IL-8 was generated from glia cells or astrocytes, not by leakage from serum. Increased IL-8 in CSF in encephalopathy may protect against severe brain damage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chemokine CCL2 / cerebrospinal fluid
Chemokine CCL2 / immunology
Chemokine CCL4 / cerebrospinal fluid
Chemokine CCL4 / immunology
Child, Preschool
Encephalitis / cerebrospinal fluid*
Encephalitis / immunology*
Female
Granulocyte Colony-Stimulating Factor / cerebrospinal fluid
Granulocyte Colony-Stimulating Factor / immunology
Granulocyte-Macrophage Colony-Stimulating Factor / cerebrospinal fluid
Granulocyte-Macrophage Colony-Stimulating Factor / immunology
Humans
Immunoassay
Infant
Interferon-gamma / cerebrospinal fluid
Interferon-gamma / immunology
Interleukins / cerebrospinal fluid*
Interleukins / immunology
Male
Seizures, Febrile / cerebrospinal fluid*
Seizures, Febrile / immunology*
Statistics, Nonparametric
Tumor Necrosis Factor-alpha / cerebrospinal fluid
Tumor Necrosis Factor-alpha / immunology

Substances

CCL4 protein, human
Chemokine CCL2
Chemokine CCL4
Interleukins
Tumor Necrosis Factor-alpha
Granulocyte Colony-Stimulating Factor
Interferon-gamma
Granulocyte-Macrophage Colony-Stimulating Factor