Abstract
Eradication of H. pylori in patients allergic to penicillin should be performed using regimens without penicillin derivatives. We treated a total of 28 patients allergic to penicillin with a proton pump inhibitor (PPI), metronidazole (250 mg bid) and sitafloxacin (100 mg bid) for one to two weeks. At four to eight weeks after the treatment, the patients underwent the [(13)C]-urea breath test. The overall eradication rate was 100.0%. Mild adverse events were observed. Triple therapy with a PPI, metronidazole and sitafloxacin is well tolerated and effective for the eradication of H. pylori in patients allergic to penicillin.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Bacterial Agents / administration & dosage*
-
Breath Tests
-
Cytochrome P-450 CYP2C19 / metabolism
-
Drug Administration Schedule
-
Drug Hypersensitivity
-
Drug Therapy, Combination
-
Female
-
Fluoroquinolones / administration & dosage*
-
Genotype
-
Helicobacter Infections / drug therapy*
-
Helicobacter Infections / epidemiology
-
Helicobacter Infections / prevention & control
-
Helicobacter pylori / drug effects*
-
Humans
-
Japan / epidemiology
-
Metronidazole / administration & dosage*
-
Middle Aged
-
Penicillins / immunology
-
Proton Pump Inhibitors / administration & dosage*
-
Retrospective Studies
-
Treatment Outcome
Substances
-
Anti-Bacterial Agents
-
Fluoroquinolones
-
Penicillins
-
Proton Pump Inhibitors
-
Metronidazole
-
sitafloxacin
-
CYP2C19 protein, human
-
Cytochrome P-450 CYP2C19