Anesthetic neurotoxicity--clinical implications of animal models

Bob A Rappaport; Santhanam Suresh; Sharon Hertz; Alex S Evers; Beverley A Orser

doi:10.1056/NEJMp1414786

Anesthetic neurotoxicity--clinical implications of animal models

N Engl J Med. 2015 Feb 26;372(9):796-7. doi: 10.1056/NEJMp1414786.

Authors

Bob A Rappaport¹, Santhanam Suresh, Sharon Hertz, Alex S Evers, Beverley A Orser

Affiliation

¹ From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (B.A.R., S.H.); Northwestern University Feinberg School of Medicine, Chicago (S.S.); Washington University School of Medicine, St. Louis (A.S.E.); and the Department of Anesthesia and Physiology, University of Toronto, Toronto (B.A.O.).

PMID: 25714157
DOI: 10.1056/NEJMp1414786

Abstract

Some anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.

MeSH terms

Anesthetics / adverse effects*
Animals
Brain / drug effects*
Child, Preschool
Humans
Hypnotics and Sedatives / adverse effects*
Learning Disabilities / chemically induced*
Models, Animal*
Postoperative Complications
Practice Guidelines as Topic*
Receptors, GABA / drug effects
Receptors, Glutamate / drug effects
Surgical Procedures, Operative*

Substances

Anesthetics
Hypnotics and Sedatives
Receptors, GABA
Receptors, Glutamate