Oncofetal reprogramming in tumour development and progression
Embryonic development is characterized by rapidly dividing cells, cellular plasticity and a
highly vascular microenvironment. These features are similar to those of tumour tissue, in …
highly vascular microenvironment. These features are similar to those of tumour tissue, in …
Review of guidelines and recommendations from 17 countries highlights the challenges that clinicians face caring for neonates born to mothers with COVID‐19
Aim This review examined how applicable national and regional clinical practice guidelines
and recommendations for managing neonates born to mothers with COVID‐19 mothers …
and recommendations for managing neonates born to mothers with COVID‐19 mothers …
[HTML][HTML] Cyclodextrin-based dermatological formulations: Dermopharmaceutical and cosmetic applications
L Ferreira, F Mascarenhas-Melo, S Rabaça… - Colloids and Surfaces B …, 2023 - Elsevier
The progress in new delivery systems for active ingredients has boosted the
dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin …
dermopharmaceutical and cosmetic fields by allowing formulations to display enhanced skin …
[HTML][HTML] Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
Mononuclear phagocytes (MNPs) encompass dendritic cells, monocytes, and macrophages
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …
(MoMac), which exhibit antimicrobial, homeostatic, and immunoregulatory functions. We …
[PDF][PDF] Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in hepatocellular carcinoma
We employed scRNA sequencing to extensively characterize the cellular landscape of
human liver from development to disease. Analysis of∼ 212,000 cells representing human …
human liver from development to disease. Analysis of∼ 212,000 cells representing human …
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models
To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
and spillovers of SARS-like betacoronaviruses (sarbecoviruses) threatening global health …
Taurine deficiency as a driver of aging
Aging is associated with changes in circulating levels of various molecules, some of which
remain undefined. We find that concentrations of circulating taurine decline with aging in …
remain undefined. We find that concentrations of circulating taurine decline with aging in …
[HTML][HTML] The retinoblastoma tumor suppressor controls androgen signaling and human prostate cancer progression
Retinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …
tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of …
[PDF][PDF] Microbial exposure during early human development primes fetal immune cells
The human fetal immune system begins to develop early during gestation; however, factors
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
responsible for fetal immune-priming remain elusive. We explored potential exposure to …
[HTML][HTML] A subset of Kupffer cells regulates metabolism through the expression of CD36
C Blériot, E Barreby, G Dunsmore, R Ballaire… - Immunity, 2021 - cell.com
Tissue macrophages are immune cells whose phenotypes and functions are dictated by
origin and niches. However, tissues are complex environments, and macrophage …
origin and niches. However, tissues are complex environments, and macrophage …